296:高选择性PARP1抑制剂和诱捕剂AZD5305基于结构和性能的药物设计

{"title":"296:高选择性PARP1抑制剂和诱捕剂AZD5305基于结构和性能的药物设计","authors":"Sudhir M. Hande, Amber Y. S. Balazs, S. Degorce, K. Embrey, Avipsa Ghosh, Sonja J. Gill, A. Gunnarsson, G. Illuzzi, Jordan Lane, C. Larner, Elisabetta Leo, A. Madin, Lisa McWilliams, M. O’Connor, Jonathan Orme, Fiona Pachl, M. Packer, A. Pike, P. Rawlins, M. Schimpl, A. Staniszewska, Andrew X. Zhang, Xiaolan Zheng, J. Johannes","doi":"10.1158/1538-7445.AM2021-296","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":9563,"journal":{"name":"Cancer Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Abstract 296: Structure-based and property-based drug design of AZD5305, a highly selective PARP1 inhibitor and trapper\",\"authors\":\"Sudhir M. Hande, Amber Y. S. Balazs, S. Degorce, K. Embrey, Avipsa Ghosh, Sonja J. Gill, A. Gunnarsson, G. Illuzzi, Jordan Lane, C. Larner, Elisabetta Leo, A. Madin, Lisa McWilliams, M. O’Connor, Jonathan Orme, Fiona Pachl, M. Packer, A. Pike, P. Rawlins, M. Schimpl, A. Staniszewska, Andrew X. Zhang, Xiaolan Zheng, J. Johannes\",\"doi\":\"10.1158/1538-7445.AM2021-296\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":9563,\"journal\":{\"name\":\"Cancer Chemistry\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1158/1538-7445.AM2021-296\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/1538-7445.AM2021-296","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}