PI3Kα在心脏保护中的作用:细胞骨架、晚期Na+电流和心律失常的机制

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Channels Pub Date : 2019-01-01 DOI:10.1080/19336950.2019.1697127

P. Zhabyeyev, Xueyi Chen, B. Vanhaesebroeck, G. Oudit

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引用次数: 10

摘要

PI3Kα (PI3Kα)是一种脂质激酶，可将磷脂酰肌醇4,5-二磷酸(PIP2)转化为磷脂酰肌醇3,4,5-三磷酸(PIP3)。PI3Kα调节多种细胞过程，如营养感知、细胞周期、迁移等。PI3Kα在多种癌症中的活性升高使其成为主要的肿瘤药物靶点，但也引起了对心脏可能产生不良影响的担忧。事实上，临床前模型的最新进展表明，PI3Kα在控制细胞骨架完整性、Na+通道活性、心脏保护和预防心律失常方面发挥了重要作用。

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PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias

ABSTRACT PI 3-kinase α (PI3Kα) is a lipid kinase that converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-triphosphate (PIP3). PI3Kα regulates a variety of cellular processes such as nutrient sensing, cell cycle, migration, and others. Heightened activity of PI3Kα in many types of cancer made it a prime oncology drug target, but also raises concerns of possible adverse effects on the heart. Indeed, recent advances in preclinical models demonstrate an important role of PI3Kα in the control of cytoskeletal integrity, Na+ channel activity, cardioprotection, and prevention of arrhythmias.

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来源期刊

Channels 生物-生化与分子生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Channels is an open access journal for all aspects of ion channel research. The journal publishes high quality papers that shed new light on ion channel and ion transporter/exchanger function, structure, biophysics, pharmacology, and regulation in health and disease. Channels welcomes interdisciplinary approaches that address ion channel physiology in areas such as neuroscience, cardiovascular sciences, cancer research, endocrinology, and gastroenterology. Our aim is to foster communication among the ion channel and transporter communities and facilitate the advancement of the field.