Exploring preclinical and clinical effectiveness of nanoformulations in the treatment of atopic dermatitis: Safety aspects and patent reviews

Atopic dermatitis (AD) is the most prevalent chronic disease that affects the skin and is featured by inflammation of the skin. Treatment of AD is entirely focused on to limit the itching, skin repairing as well as reducing the inflammation whenever required. A number of therapeutic agents are available for the treatment of AD. However, topical delivery to the skin has been a consistent challenge for researchers, because of the barrier nature of skin. The present review explores the novel nano-sized formulations of various actives researched for AD therapy via topical route. Feasibility of various nano-carrier systems such as elastic vesicles, nanoemulsions, lipid nanoparticles, polymeric micelles and dendritic nanoparticles has been elaborated. The write up traces the pre-clinical and clinical aspects of the nano-formulations. Nano-formulations are found to be an emerging modality for the treatment of AD as they offer targeted delivery, better penetration, enhanced therapeutic efficacy and decreased systemic side effects.