Pseudomembranous小肠结肠炎;用金黄色葡萄球菌及其肠毒素诱导疾病的实验。

J. Prohaska
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引用次数: 26

摘要

反对将金黄色葡萄球菌(化脓性微球菌)作为假膜性肠炎的病原,是因为观察到并非在所有病例中都分离出葡萄球菌,并且假设在肠道中观察到的物理变化是继发于相关的休克。这些反对意见毫无根据。金黄色葡萄球菌并不是在每种培养基上都能生长出来。在混合菌群中,它根本长不出来,除非培养基有利于它的生长并抑制与之竞争的微生物。转诊医生反复告诉我,他们的病人的粪便培养,假膜性小肠结肠炎的绝望,没有生长出葡萄球菌。在适当培养基上培养这些患者的粪便时,葡萄球菌以优势比例生长。对猴子这种对肠毒素高度敏感的动物口服葡萄球菌不会使它们生病,也不会引起大便
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pseudomembranous enterocolitis; the experimental induction of the disease with Staphylococcus aureus and its enterotoxin.
The objection to Staphylococcus var. aureus (Micrococcus pyogenes) as the etiologic agent of pseudomembranous enteritis stems from the observation that Staphylococcus has not been isolated in every case of the disease and from the assumption that the physical changes observed in the intestine are secondary to the associated shock. These objections are without foundation. S. aureus does not grow out on every culture medium. In a mixed flora it fails to grow out at all, unless the culture medium favors its growth and suppresses the competing micro-organism. Referring physicians have told me repeatedly that the stool cultures of their patients, desperately sick with pseudomembranous enterocolitis, did not grow out staphylococci. Upon culturing the stools of these patients on proper media the staphylococci grew out in dominant Proportions. The oral administration of staphylococci to monkeys, animals highly sensitive to the enterotoxin, does not make them sick and does not induce stools
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