锂诱发甲状旁腺病;更新的迷你评论

Leila Mahmoodnia
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摘要

锂是一种通常用于治疗双相情感障碍和其他精神疾病的药物。然而,长期使用锂可导致甲状旁腺功能障碍,称为锂诱导的甲状旁腺疾病。锂诱发甲状旁腺疾病的确切机制尚不完全清楚。尽管如此,人们认为锂通过抑制甲状旁腺激素(PTH)的合成和分泌以及损害甲状旁腺对钙的敏感性来干扰甲状旁腺的正常功能。锂诱导的甲状旁腺疾病的治疗取决于甲状旁腺功能障碍的类型和严重程度。对于甲状旁腺功能减退症患者,治疗包括补钙和补充维生素D。在严重的情况下,静脉补钙是必要的。对于甲状旁腺功能亢进患者,治疗包括停止锂治疗和监测血清钙和甲状旁腺激素水平。如果甲状旁腺功能亢进持续存在,或者出现肾结石或骨质疏松等并发症,手术可能是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lithium-induced parathyroid disease; an updated mini-review
Lithium is a medication commonly used to treat bipolar disorder and other psychiatric conditions. However, long-term use of lithium can lead to parathyroid dysfunction, known as lithium-induced parathyroid disease. The exact mechanism underlying lithium-induced parathyroid disease is not fully understood. Still, it is believed that lithium interferes with the normal function of the parathyroid gland by inhibiting the synthesis and secretion of parathyroid hormone (PTH) and impairing the sensitivity of the parathyroid gland to calcium. The management of lithium-induced parathyroid disease depends on the type and severity of parathyroid dysfunction. In patients with hypoparathyroidism, treatment involves the replacement of calcium and vitamin D supplements. In severe cases, intravenous calcium may be necessary. In patients with hyperparathyroidism, treatment consists in discontinuing lithium therapy and monitoring serum calcium and PTH levels. In situations where hyperparathyroidism persists, or complications like kidney stones or osteoporosis arise, surgery may become necessary.
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