人Fas配体胞外结构域:生物化学表征、工程衍生物生产和医学应用的现状

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M. Muraki
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引用次数: 0

摘要

人Fas配体胞外结构域(hFasLECD)是一种可溶性蛋白制剂,由于亲本膜结合的Fas配体(CD95L, CD178)在人体内具有重要的免疫功能,因此与医学有重要的相关性。本文旨在概述hFasLECD的研究现状,从其基本的分子特性和生物活性到其作为一种新的、实用的细胞死亡诱导疗法或疾病生物标志物的潜力。本文主要从人体Fas配体的生物学功能背景、hFasLECD的基本生化特性、工程hFasLECD衍生物的制备、hFasLECD在医学上的应用潜力等四个方面进行综述。在基础科学和工程相关领域面向临床应用的研究工作的基础上,hFasLECD转化为医学上的既定药物正在进行中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human Fas ligand extracellular domain: current status of biochemical characterization, engineered-derivatives production, and medical applications
Human Fas ligand extracellular domain (hFasLECD) is a soluble protein agent with significant relevance to medicine because of the immunologically essential functions of parental membrane-bound Fas ligand (CD95L, CD178) in the human body. This paper aimed to overview the current status of the studies focused on hFasLECD, ranging from its fundamental molecular properties and biological activity to its potential as a novel, practical cell death-inducing therapeutics or a diseases biomarker. The main part of this review was divided into four sections, the background of biological functions of human Fas ligand, the fundamental biochemical characteristics of hFasLECD, the production of engineered hFasLECD derivatives, and the potential of hFasLECD for medical applications. The translation of hFasLECD into an established agent in medicine is in progress, based on the clinical use-oriented research works in the relevant fields of basic science and engineering.
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来源期刊
AIMS Medical Science
AIMS Medical Science MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
14.30%
发文量
20
审稿时长
12 weeks
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