黄柏树皮提取物的抗炎和抗氧化作用

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-07-30 DOI:10.37360/blacpma.23.22.4.35

M. J. A. Silva, A. P. Boleti, L. Acho, J. F. Campos, J. P. Neto, A. Guimarães, Felipe M. A. Silva, H. Koolen, E. L. Santos, E. Lima

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引用次数: 0

摘要

巴西坚果原产于亚马逊雨林，俗称巴西坚果。它具有重要的社会经济意义，因为它的坚果是一种很好的出口产品。文献中关于其树皮的生物技术潜力的研究很少，尽管它被用于民间医学。本研究的目的是测定黄芩提取物(BEB)的化学成分、抗炎和抗氧化性能。通过LC/MS/MS鉴定了12种物质，进行了细胞毒性试验，并分析了一氧化氮的产生和自由基的消除。BEB引起巨噬细胞对氧化应激的细胞保护，增加HMOX-1的表达，克服GPx-1的抗氧化作用并降低其表达，能够抑制白细胞在使用性腹膜炎中的迁移。由于其抗氧化和抗炎特性，BEB有效地减轻了氧化应激，因此，可以作为一种安全有效的天然草药来源。

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Anti-inflammatory and antioxidant properties of Bertholletia excelsa(H.B.K) bark extract

Bertholletia excelsais native to the Amazon Rainforest and is popularly known as the Brazil nut. It has socioeconomic importance due its nuts being a great export product. There are fewstudies in the literature regarding the biotechnological potential of its bark, although it is used in folk medicine. The aim of this study was to determine the chemical constituents, anti-inflammatory and antioxidant properties of B. excelsabark extract(BEB). Twelve substances were identified by LC/MS/MS, and cytotoxicity tests were carried out, as well as analyses of nitric oxide production and elimination of free radicals. BEB caused cytoprotection against oxidative stress in macrophages, increased HMOX-1 expression, overcame the antioxidant effects of GPx-1 and reduced its expression and was able to inhibit leukocyte migration in use peritonitis. BEB efficiently attenuated oxidative stress due to its antioxidant and anti-inflammatory properties and, as such, can be used as a safe and effective source of a natural herbal medicine.

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.