伊拉克埃尔比勒市乳糜泻患者抗麦胶蛋白(IgA和IgG)、促甲状腺激素和生长激素水平的测定

Zaid N. Elia, S. Hussain, Nisreen W. Mustafa
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摘要

乳糜泻(CD)是一种自身免疫性人类白细胞抗原hla相关的肠病,在摄入含麸质的饮食后发生,以腹泻、吸收不良和体重减轻为主要表现。本病与许多肠道外疾病,特别是内分泌疾病密切相关。本研究旨在评估新诊断(ND)乳糜泻和无麸质饮食(GFD)患者的促甲状腺激素(TSH)和生长激素(GH)水平。对26/50新诊断的乳糜泻患者和20例GFD患者进行临床诊断并经抗麦胶蛋白IgA和IgG(IgA诊断为新诊断,IgG诊断为GFD)血清学证实的促甲状腺激素(TSH)和生长激素(GH)水平进行评估。乳糜泻患者抗麦胶蛋白IgA和IgG阳性率为82%,GFD患者阳性率为80%。在儿童中,82.14%的新诊断和85.71%的GFD患者IgA和IgG抗麦胶蛋白血清阳性,而在成人中,81.82%的新诊断和76.92%的GFD患者IgA和IgG抗麦胶蛋白血清阳性。结果显示:GFD患者血清TSH水平分别升高80.77%和30%;同时,73.07%的CD和10%的GFD患者GH水平较低。在同一患者中,CD患者tsh升高和GH低的发生率分别为69.23%和10%。因此,本研究描述了CD疾病和亚临床甲状腺功能减退之间的同时发生和联系。此外,对乳糜泻患者的ghr水平进行评估是必要的,作为垂体紊乱的标志,可能是自身免疫性的起源。在新诊断和GFD患者中,抗麦胶蛋白抗体与TSH和GH水平无显著相关性。ND患者TSH和GH (r=- 0.568, P=0.002)与GFD患者TSH和GH (r=- 0.702, P= 0.001)具有显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Anti–Gliadin (IgA & IgG), Thyroid Stimulating Hormon and Growth Hormon Level in Celiac Disease Patients in Erbil City – IRAQ
Celiac disease (CD) is an autoimmune human leukocyte antigen HLA–linked enteropathy that develop upon ingestion of gluten containing diet, withdiarrhea, malabsorption and weight loss as a major presentation.The disease is closely linked to a number of extra intestinal disorderespecially endocrine diseases. This study aimed to assess level of thyroidstimulation hormone (TSH) and growth hormone (GH) level in patients with newlydiagnosed (ND) CD and on gluten free diet (GFD)A total of 26/50 newly diagnosed celiac disease patients and 20 on GFDdiagnosed clinically and confirmed serologically using anti-gliadin IgA and IgG(IgA for diagnosis newly diagnosed and IgG for diagnosis of patients on GFD)were subjected to TSH and GH level assessment.The anti-gliadin IgA and IgG were positive in 82% with celiac patients and80% on GFD patients. Among children , 82.14% of newly diagnosed and 85.71%on GFD were IgA and IgG anti-gliadin seropositive, while in adults, 81.82% and76.92 % of newly diagnosed and on GFD were IgA and IgG anti-gliadinseropositive respectively. The results revealed elevated TSH level in sera of 80.77% and 30% of CDand on GFD patients respectively; meanwhile GH level was low in 73.07% and10% of CD and GFD patients respectively. The frequency CD patients revealedTSH elevation and low GH in the same patient was 69.23 % and 10% in CD and onGFD patients respectively.As a result, the present study delineated simultaneous occurrence and linkagebetween CD disease and subclinical hypothyroidism. Beside assessment of GHlevel in CD patients is necessary as marker for disorder of pituitary gland, possiblyof autoimmune origin.In newly diagnosed and patients on GFD patients, no significant correlation existsbetween anti-gliadin antibodies, TSH & GH level. Meanwhile significantcorrelation was found between TSH & GH in ND (r= - 0.568, P=0.002) & GFD (r=- 0.702, P= 0.001).
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