使用新型合金纳米颗粒分析小代谢物

2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) Pub Date : 2017-08-01 DOI:10.1109/3M-NANO.2017.8286304

Jingyi Huang, D. Gurav, Xiang Wei, Lin Huang, Xuming Sun, S. Wu, Haiyang Su, Kun Qian

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引用次数: 0

摘要

我们展示了一种基于激光解吸/电离质谱(LDI MS)的代谢物检测方法，该方法以Au/Pd合金纳米晶体为新型基质。由于该合金独特的结构特征，该合金具有灵敏的LDI性能，可用于标准小分子检测和血清样品的代谢分析。我们的方法在几分钟内提供了方便的样品制备，样品消耗量低至10 nL，可用于实际应用。这项工作揭示了基于材料的LDI质谱分析使用设计的诊断工具的小分子量代谢物。

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Analysis of small metabolites using novel alloy nanoparticles

We demonstrated a laser desorption/ionization mass spectrometry (LDI MS) based metabolite detection method using Au/Pd alloy nanocrystals as novel matrix. A sensitive LDI performance for detection of standard small molecules and metabolic analysis of serum samples was achieved owing to the unique structural feature of the alloy. Our approach offered facile sample preparation within minutes and low sample consumption down to ∼10 nL for practical application. This work shed light on material based LDI MS analysis of small molecular weight metabolites using designed diagnostic tools.

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来源期刊

2017 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)

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