经颅电刺激对模拟高血压犬血压的影响

O. Sein, Olga Tatiyanicheva, K. Mikhaĭlov, A. Shevchenko, I. Boiko, N. Maslova
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摘要

本文描述了经颅电刺激(TES)矫正犬血压(BP)的结果。实验过程中记录收缩压(bp)、舒张压(BPd)、脉压(PP)和平均血压(MBP)。实验证明,将固定在动物头部的电极以恒电流(从0到6 mA逐渐增加)通电,再切换到75 Hz 4.0 mA方波脉冲(脉冲持续时间- 3.5 ms) 30分钟的TES模式对药理学模拟的高血压狗的血压有矫正作用。实验结果显示,注射美沙酮、米多卡因和去甲肾上腺素后,所有犬的血压指标均升高。药物联合TES给药组动物BP参数升高无统计学意义(p>0.05)。在对照组狗中,大多数情况下血压参数显著升高(p<0.05)。在美沙酮联合TES组中观察到研究参数之间最显著的差异。结果显示,试验组动物注射TES后,bp值在139.7±8.8 ~ 146.6±8.7之间;BPd范围为78.8±6.8 ~ 80.0±5.0;Pp - 60.0±5.8 - 67.8±5.7;MBP - 99.7±7.8 - 101.4±7.0 mmHg。未接受TES治疗的对照组动物的参数值更高,范围在151.0±8.8 ~ 170.5±8.9之间;80.3±6.4 - 98.9±7.3;70.0±7.0 - 71.6±6.9;103.9±8.0 - 122.8±8.1 mmHg。建议在实际兽医中使用TES来矫正犬的血压。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Influence of Transcranial Electrostimulation on Blood Pressure in Dogs with Modeled Hypertension
The present article describes the results of the transcranial electrostimulation (TES) for the correction of blood pressure (BP) in dogs. During the experiment, systolic blood pressure (BPs), diastolic blood pressure (BPd), pulse pressure (PP), and mean blood pressure (MBP) were registered. It was established that TES mode that switched on the electrodes feeding that were fixed on the animal head at constant current (gradually increasing from 0 to 6 mA) with further switching to 75 Hz 4.0 mA square-wave pulse (impulse duration – 3.5 ms) for 30 minutes exerted corrective effect on blood pressure in dogs with pharmacologically modeled hypertension. The results of the performed tests showed that after the injection of mesatone, midodrine, and norepinephrine, the studied BP parameters elevated in all the dogs. In animals from the test groups that were injected drugs in combination with TES, the BP parameters increased insignificantly (p>0.05). In the dogs from the control groups, the increase in the BP parameters was significant in the majority of cases (p<0.05). The most significant differences between the studied parameters were observed in groups that received mesatone in combination with TES. It was revealed that after the injection of the drug and performance of TES in animals from the test group, BPs ranged within 139.7±8.8 – 146.6±8.7; BPd ranged within 78.8±6.8 – 80.0±5.0; PP – 60.0±5.8 – 67.8±5.7; MBP – 99.7±7.8 – 101.4±7.0 mmHg. In animals from the control group that did not receive TES, the parameter values were higher and ranged within 151.0±8.8 – 170.5±8.9; 80.3±6.4 – 98.9±7.3; 70.0±7.0 – 71.6±6.9; 103.9±8.0 – 122.8±8.1 mmHg, respectively. It is recommended to use TES in practical veterinary to the correction of blood pressure in dogs.
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