移植后胆道狭窄:最新综述。

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Seminars in liver disease Pub Date : 2022-03-09 DOI:10.1055/s-0042-1744144

Matthew Fasullo, T. Shah, Huiping Zhou, M. Siddiqui

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引用次数: 2

摘要

肝移植(LT)是终末期肝病患者唯一的治疗方法，具有良好的长期生存率;然而，肝移植受者有明显并发症的风险。在这些并发症中，胆道并发症的发生率从5%到32%不等，并与肝移植后显著的发病率和死亡率相关。及时识别和处理是至关重要的，因为这些并发症与死亡率高达19%和再移植率高达13%相关。已发表的研究的一个重要限制是，很大一部分没有区分吻合口狭窄和非吻合口狭窄。本综述旨在总结我们目前对肝移植后胆道狭窄的危险因素、自然病史、诊断测试和治疗方案的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Post-Transplant Biliary Strictures: An Updated Review.

Liver transplantation (LT) is the only curative therapy in patients with end-stage liver disease with excellent long-term survival; however, LT recipients are at risk of significant complications. Among these complications are biliary complications with an incidence ranging from 5 to 32% and associated with significant post-LT morbidity and mortality. Prompt recognition and management are critical as these complications have been associated with mortality rates up to 19% and retransplantation rates up to 13%. An important limitation of published studies is that a large proportion does not discriminate between anastomotic strictures and nonanastomotic strictures. This review aims to summarize our current understanding of risk factors and natural history, diagnostic testing, and treatment options for post-LT biliary strictures.

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来源期刊

Seminars in liver disease 医学-胃肠肝病学

CiteScore

8.20

自引率

2.40%

发文量

期刊介绍： Seminars in Liver Disease is a quarterly review journal that publishes issues related to the specialties of hepatology and gastroenterology. As the premiere review journal in the field, Seminars in Liver Disease provides in-depth coverage with articles and issues focusing on topics such as cirrhosis, transplantation, vascular and coagulation disorders, cytokines, hepatitis B & C, Nonalcoholic Steatosis Syndromes (NASH), pediatric liver diseases, hepatic stem cells, porphyrias as well as a myriad of other diseases related to the liver. Attention is also given to the latest developments in drug therapy along with treatment and current management techniques. Seminars in Liver Disease publishes commissioned reviews. Unsolicited reviews of an exceptional nature or original articles presenting remarkable results will be considered, but case reports will not be published.