负载多酚的介孔二氧化硅系统

G. Petrișor, Ludmila Motelica, R. Trusca, V. Ene, D. Ficai, O. Oprea, G. Voicu, A. Ficai
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引用次数: 0

摘要

在这项工作中,我们获得了负载多酚化合物(对香豆酸、反式阿魏酸、表儿茶素和儿茶素)的介孔二氧化硅系统。多酚类化合物被用作治疗各种疾病的生物活性剂。这些化合物具有很高的抗氧化活性。以十六烷基三甲基溴化铵(CTAB)为载体,在碱性条件下采用经典模板法制备了两种介孔二氧化硅。多酚类物质(对香豆酸、反式阿魏酸、表儿茶素和儿茶素)在真空条件下装入介孔二氧化硅中。采用扫描电子显微镜、x射线衍射、brunauer - emmet - teller方法、复热分析- dta - tg和傅里叶变换红外光谱对所得材料进行了表征。在这项研究中,获得了介孔二氧化硅体系,并进一步负载了对香豆酸、反式阿魏酸、表儿茶素和儿茶素。结果表明,这些材料可以作为药物传递系统,在各种环境下(模拟胃液,SGF和模拟肠液,SIF)的结果是有希望的。所提出的加载方法适用于在孔隙内部加载这些天然剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesoporous Silica Systems Loaded with Polyphenols
In this work, we obtain mesoporous silica systems loaded with polyphenolic compounds (p-coumaric acid, trans-ferulic acid, epicatechin, and catechin). Polyphenolic compounds are used as biologically active agents for the treatment of various diseases. These compounds have high antioxidant activity. As a carrier, two types of mesoporous silica have been proposed and obtained according to the classical templating method with cetyltrimethylammonium bromide, CTAB, under alkaline conditions. Polyphenols (p-coumaric acid, trans-ferulic acid, epicatechin, and catechin) were loaded under vacuum into the mesoporous silica. The materials obtained were characterized by Scanning Electron Microscopy, X-ray Diffraction, the Brunauer–Emmett–Teller Method, Complex Thermal Analysis–DTA-TG and Fourier Transform Infrared Spectroscopy. In this study, mesoporous silica systems were obtained and further loaded with p-coumaric acid, trans-ferulic acid, epicatechin and catechin. The results highlight that the materials can be used as drug delivery systems, with the results being promising (simulated gastric fluid, SGF, and simulated intestinal fluid, SIF) for various environments. The proposed loading methodology is suitable for loading these natural agents, mostly, inside the pores.
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