乙型肝炎病毒共价闭合环状DNA的替代标记物。

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Seminars in liver disease Pub Date : 2022-04-20 DOI:10.1055/a-1830-2741

T. Tu, Florian van Boemmel, T. Berg

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引用次数: 1

摘要

慢性乙型肝炎病毒(HBV)感染是世界范围内肝脏疾病最常见的原因之一。慢性HBV感染目前是无法治愈的，因为病毒转录物的病毒模板，共价闭合环(cccDNA)的持久性。检测cccDNA转录活性的变化是了解基本病毒学、确定新疗法疗效和确定HBV患者最佳临床管理的关键。在这篇综述中，我们总结了用于推断慢性乙型肝炎患者cccDNA水平和活性的替代循环生物标志物。此外，我们概述了当前生物标志物的不足之处，并强调了改进和扩大其应用的临床重要性。

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Surrogate markers for hepatitis B Virus covalently closed circular DNA.

Chronic infection with the Hepatitis B virus (HBV) is one of the most common causes of liver disease worldwide. Chronic HBV infection is currently incurable because of the persistence of the viral template for the viral transcripts, covalently closed circular (cccDNA). Detecting changes in cccDNA transcriptional activity is key to understanding fundamental virology, determining the efficacy of new therapies, and deciding the optimal clinical management of HBV patients. In this review, we summarize surrogate circulating biomarkers that have been used to infer cccDNA levels and activity in people with chronic hepatitis B. Moreover, we outline the current shortcomings of the current biomarkers and highlight the clinical importance in improving them and expanding their use.

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来源期刊

Seminars in liver disease 医学-胃肠肝病学

CiteScore

8.20

自引率

2.40%

发文量

期刊介绍： Seminars in Liver Disease is a quarterly review journal that publishes issues related to the specialties of hepatology and gastroenterology. As the premiere review journal in the field, Seminars in Liver Disease provides in-depth coverage with articles and issues focusing on topics such as cirrhosis, transplantation, vascular and coagulation disorders, cytokines, hepatitis B & C, Nonalcoholic Steatosis Syndromes (NASH), pediatric liver diseases, hepatic stem cells, porphyrias as well as a myriad of other diseases related to the liver. Attention is also given to the latest developments in drug therapy along with treatment and current management techniques. Seminars in Liver Disease publishes commissioned reviews. Unsolicited reviews of an exceptional nature or original articles presenting remarkable results will be considered, but case reports will not be published.