Zone of Inhibition of Phenol and Lysol Antimetabolites against Growth of Pseudomonas aeruginosa (A Literature Study)

Phenols are the oldest antimetabolites that are often used as disinfectants or microbiosides. Phenols are aromatic compounds that have a distinctive odor and include derivatives of benzene (C6H6). Phenol has a germicidal effect that causes protein denaturation and has active substances on the surface (surfactants) so that it can damage cell membrans and control the growth of microbes that can prevent nosocomial infections in hospitals. Pseudomonas aeruginosa is a Gram-negative bacteria that can live on medical equipment and other parts of the hospital that can cause post-surgical infections.The aims of research to determine the inhibition of phenol antimetabolites against Pseudomonas aeruginosa.Through a literature study of several research results that have been published in scientific journals, it is known that the method and concentration used are very influential in testing the inhibition of phenol antimetabolites on the growth of Pseudomonas aeruginosa bacteria. The results of several literature searches state that phenol antimetabolites are only able to inhibit the growth of Pseudomonas aeruginosa with a weak strength of 4±0,5 - 11 mm. In Lysol which is a phenol antimetabolite that reacts with halogens, there is a large difference in the zone of strong (sensitive) inhibition, which is influenced by a large concentration with the greatest inhibitory strength at concentrations of 75% and 100%, with a diameter of 26 mm. From the results of research that has been done it can be concluded that, phenol antimetabolites can inhibit Pseudomonas aeruginosa.