金属卟啉增敏剂在肿瘤治疗和诊断中的应用

Journal of Chemical Research-s Pub Date : 2022-03-01 DOI:10.1177/17475198221090914

Hongyu Luo, Wenmei Yu, Si Chen, Zhenyu Wang, Zejie Tian, Jun He, Yunmei Liu

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引用次数: 0

摘要

目前，金属卟啉化合物主要有三种抗癌增敏剂的用途:(1)光敏剂，(2)光热转化剂，(3)超声增敏剂。开发具有良好可控性和生物相容性的高效致敏剂是肿瘤医学的重要目标。由于抗癌增敏剂的结构多样性不同，这些增敏剂被用于治疗癌症，采用了多种肿瘤治疗方法，如成熟的光动力疗法、临床上常用的光热疗法和有前景的声动力疗法。在众多增敏剂中，金属卟啉复合物增敏剂因其在肿瘤治疗和诊断中的优异表现而受到广泛关注。本文简要介绍了与光动力、光热和声动力治疗相关的金属卟啉类抗癌药物和诊疗剂，并讨论了金属原子在这些药物中的作用。

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Application of metalloporphyrin sensitizers for the treatment or diagnosis of tumors

At present, metalloporphyrin compounds demonstrate three main uses as anticancer sensitizers: (1) photosensitizers, (2) photothermal conversion agents, and (3) ultrasound sensitizers. Developing efficient sensitizers for cancer with excellent controllability and biocompatibility is an important goal of oncology medicine. Because of the different structural diversity of anticancer sensitizers, such sensitizers are used for treating cancers by employing a variety of tumor treatment methods such as mature photodynamic therapy, commonly used clinically photothermal therapy and promising sonodynamic therapy. Among the many sensitizers, metalloporphyrin-complex sensitizers attract wide attention due to their excellent performance in tumor treatment and diagnosis. This review briefly describes some metalloporphyrin anticancer drugs and diagnostic agents related to photodynamic, photothermal and sonodynamic therapy, and discusses the roles of metal atoms in these drugs.

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.