{"title":"左乙拉西坦药物对胚胎大鼠肾脏发育的致畸作用","authors":"Lamyaa H. M. Al-Ibrahimi, N. Al-Bakri","doi":"10.30526/2017.IHSCICONF.1768","DOIUrl":null,"url":null,"abstract":"The new antiepileptic drugs, levetiracetam (LEV), are used to treat tonic-clonic seizures and myoclonic seizures in adults and children. Thirty pregnant rats were enrolled, which were divided into two groups A control (10), B treated (20). Group (A) were given distilled water orally for 15 days of pregnancy period. The other group was subdivided into two subgroups B1, B2 (each with 10 rats), which were treated with LEV for 14 days for subgroup (B1) and 15 days for the other subgroup (B2). The drug (350 mg/kg/day) is administered orally. Based on our results there was damage in the kidney due to the toxicity of the drug. The histopathological effects is represented by damage of cortical glomeruli in which there were hemorrhage, shrinking, accumulation of glomerular cells, and enlargement of capsular space. Severe malformations in the kidney were observed when the drug is used constantly during the organogenesis stages of pregnancy.","PeriodicalId":13236,"journal":{"name":"Ibn Al-Haitham Journal For Pure And Applied Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Teratogenic Effect of Levetiracetam Drug on the Development of the Kidney in Embryo Rat\",\"authors\":\"Lamyaa H. M. Al-Ibrahimi, N. Al-Bakri\",\"doi\":\"10.30526/2017.IHSCICONF.1768\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The new antiepileptic drugs, levetiracetam (LEV), are used to treat tonic-clonic seizures and myoclonic seizures in adults and children. Thirty pregnant rats were enrolled, which were divided into two groups A control (10), B treated (20). Group (A) were given distilled water orally for 15 days of pregnancy period. The other group was subdivided into two subgroups B1, B2 (each with 10 rats), which were treated with LEV for 14 days for subgroup (B1) and 15 days for the other subgroup (B2). The drug (350 mg/kg/day) is administered orally. Based on our results there was damage in the kidney due to the toxicity of the drug. The histopathological effects is represented by damage of cortical glomeruli in which there were hemorrhage, shrinking, accumulation of glomerular cells, and enlargement of capsular space. Severe malformations in the kidney were observed when the drug is used constantly during the organogenesis stages of pregnancy.\",\"PeriodicalId\":13236,\"journal\":{\"name\":\"Ibn Al-Haitham Journal For Pure And Applied Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ibn Al-Haitham Journal For Pure And Applied Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30526/2017.IHSCICONF.1768\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ibn Al-Haitham Journal For Pure And Applied Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30526/2017.IHSCICONF.1768","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
新型抗癫痫药物左乙拉西坦(LEV)用于治疗成人和儿童的强直-阵挛性发作和肌阵挛性发作。选取孕鼠30只，分为对照组(10只)和治疗组(20只)。A组小鼠妊娠期灌胃蒸馏水15 d。另一组再分为B1、B2两个亚组(每组10只大鼠)，分别给予LEV治疗14 d和15 d (B1亚组)。该药物(350mg /kg/天)口服。根据我们的结果，由于药物的毒性，肾脏受到了损害。组织病理学影响表现为肾小球皮质损伤，表现为出血、萎缩、肾小球细胞积聚和囊腔增大。在妊娠器官发生阶段，持续使用该药可观察到严重的肾脏畸形。
Teratogenic Effect of Levetiracetam Drug on the Development of the Kidney in Embryo Rat
The new antiepileptic drugs, levetiracetam (LEV), are used to treat tonic-clonic seizures and myoclonic seizures in adults and children. Thirty pregnant rats were enrolled, which were divided into two groups A control (10), B treated (20). Group (A) were given distilled water orally for 15 days of pregnancy period. The other group was subdivided into two subgroups B1, B2 (each with 10 rats), which were treated with LEV for 14 days for subgroup (B1) and 15 days for the other subgroup (B2). The drug (350 mg/kg/day) is administered orally. Based on our results there was damage in the kidney due to the toxicity of the drug. The histopathological effects is represented by damage of cortical glomeruli in which there were hemorrhage, shrinking, accumulation of glomerular cells, and enlargement of capsular space. Severe malformations in the kidney were observed when the drug is used constantly during the organogenesis stages of pregnancy.
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