探索药物-表面活性剂的相互作用及其对水溶介质的内在表面性质的影响

Phoebe Greensides, Mark McAllister, Inese Sarcervica, I. Tomaszewska
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引用次数: 0

摘要

表面活性剂常用于提高化合物在水介质中的溶解度。在观察到表面活性剂浓度增加的非线性溶解度增强后,本研究考察了难溶性、两性离子、中等亲脂性药物化合物a对磷酸缓冲液中十二烷基硫酸钠临界胶束浓度(CMC)的影响。用力张力计测量溶液在一定表面活性剂浓度范围内的表面张力。化合物A的存在表明CMC的减少,这表明在药物存在的情况下,溶液在较低的表面活性剂浓度下有利于胶束化。未来的研究将使用化合物a的完全饱和溶液来进一步探索这一观察结果。其他实验也将研究SLS与其他化合物的胶束形成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring drug-surfactant interactions and their impact on the intrinsic surface properties of aqueous dissolution media
Surfactants are often used to improve the solubility of a compound for dissolution studies in aqueous media. Having observed non-linear solubility enhancement with increasing surfactant concentration, this study investigated the effect of a poorly soluble, zwitterionic, moderately lipophilic drug, Compound A, on the critical micelle concentration (CMC)of sodium lauryl sulfate (SLS) in phosphate buffer. A force tensiometer was used to measure the surface tension of the solutions over a range of surfactant concentrations. The presence of Compound A demonstrated a decrease in the CMC, suggesting that the solution favours micellisation at lower surfactant concentrations in the presence of the drug. Future studies will use a fully saturated solution of Compound A to explore this observation further. Additional experiments will also investigate micelle formation of SLS with other compounds.
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