纳米植物医学在临床管理中的应用:基于证据的综述

M. Jahangir
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引用次数: 5

摘要

草药是传统和替代医学体系的重要组成部分,自古以来就被使用。由于其副作用小、治疗效果潜在的特点,引起了世界各国药学界的关注。目前,草药已在全球占据了高达620亿美元的市场。草药因其治疗慢性疾病的潜力、低毒性、廉价和广泛可得等而被广泛接受。方法:中药的安全性和有效性是其成功商业化的重要因素。随着纳米技术的出现和应用,草药的生物利用度和生物活性得到了极大的提高。结果:纳米植物药的开发通过将其尺寸缩小到纳米尺度范围,与聚合物结合,并通过改变其表面性质,溶解度,渗透性,最终提高了草药配方的生物利用度。结论:乳质体、脂质体、纳米微球、光光体等新型制剂在该领域具有广阔的开发前景。然而,新型纳米植物药物有其自身的优点和缺点。本文广泛回顾了草药纳米药物的成功和失败。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanophytomedicine in Clinical Management: An Introductory Evidence-based Review
Introduction: Herbal medicines are an important ingredient of traditional and alternative medicinal system and thus being used since ancient times. Owing to their characteristic of having lesser side effects and potential therapeutic effect they have drawn attention of pharmaceutical scientists from across the globe. Herbal medicines have now strongly captured a whooping US $62 billion market globally. Herbal medicines have been widely accepted of their potential to treat chronic diseases, low toxicity profile, cheap and wide availability etc. Methods: The Safety and efficacy of herbal drugs have played an important part in their successful commercialization. With the emergence and application of nanotechnology the bioavailability and bioactivity of herbal medicines have improved drastically. Results: Development of nano-phytomedicines by reducing their size to nano scale range, attaching it with polymers and by modifying their surface properties, solubility, permeability, eventually enhances the bioavailability of herbal formulations. Conclusion: Novel formulations like niosomes, liposomes, nanospheres, phytosomes etc. can be exploited in this area. However, novel nano-phytomedicines comes with its own pros and cons. This article extensively reviews herbal nano-medicines with its reported success and failures.
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