山苍子甲醇提取物抗氧化、镇痛和止泻活性的研究叶子

Md. Razowanul Ferdous, Ashrafudoulla, Md Shohel Hossain, S. Bellah
{"title":"山苍子甲醇提取物抗氧化、镇痛和止泻活性的研究叶子","authors":"Md. Razowanul Ferdous, Ashrafudoulla, Md Shohel Hossain, S. Bellah","doi":"10.4172/2167-065x.1000185","DOIUrl":null,"url":null,"abstract":"Antioxidant, analgesic and antidiarrheal activities of Litsea monopetala (LM) leaves extracts were investigated in order to assessment of pharmacological activities. In vitro antioxidant properties, in vivo analgesic and antidiarrheal activities were investigated in this study. Antioxidant plays a remarkable role to protect different kinds of diseases of human by inhibiting free radicals. 1, 1-diphenyl-2picrylhydrazyl (DPPH) free radical scavenging was considered to evaluate the antioxidant property. Analgesic and antidiarrheal activities were investigated in acetic acid induced writhing and castor oil induced antidiarrheal method by white albino mice, respectively. Methanolic extract of LM leaves has shown antioxidant activity with an IC50 value of 223.22 μg/ml which was compared to the standard ascorbic acid. This extract of LM at a dose of 500 mg/kg showed statistically significantly (p<0.001) and produced 68.75% writhing inhibition of mice while standard diclofenac sodium drug has shown 76.25% inhibition. LM also produced a significant (P<0.01) reduction in the frequency of diarrhea produced by castor oil in mice compared with Loperamide (50 mg/kg) standard. This study clearly supports the medicinal value of LM`s leaves. However, further study is required to find out the active components which are responsible for these activities.","PeriodicalId":10410,"journal":{"name":"Clinical Pharmacology & Biopharmaceutics","volume":"151 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Evaluation of Antioxidant, Analgesic and Antidiarrheal Activities of Methanolic Extract of Litsea monopetala (roxb.) Leaves\",\"authors\":\"Md. Razowanul Ferdous, Ashrafudoulla, Md Shohel Hossain, S. Bellah\",\"doi\":\"10.4172/2167-065x.1000185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Antioxidant, analgesic and antidiarrheal activities of Litsea monopetala (LM) leaves extracts were investigated in order to assessment of pharmacological activities. In vitro antioxidant properties, in vivo analgesic and antidiarrheal activities were investigated in this study. Antioxidant plays a remarkable role to protect different kinds of diseases of human by inhibiting free radicals. 1, 1-diphenyl-2picrylhydrazyl (DPPH) free radical scavenging was considered to evaluate the antioxidant property. Analgesic and antidiarrheal activities were investigated in acetic acid induced writhing and castor oil induced antidiarrheal method by white albino mice, respectively. Methanolic extract of LM leaves has shown antioxidant activity with an IC50 value of 223.22 μg/ml which was compared to the standard ascorbic acid. This extract of LM at a dose of 500 mg/kg showed statistically significantly (p<0.001) and produced 68.75% writhing inhibition of mice while standard diclofenac sodium drug has shown 76.25% inhibition. LM also produced a significant (P<0.01) reduction in the frequency of diarrhea produced by castor oil in mice compared with Loperamide (50 mg/kg) standard. This study clearly supports the medicinal value of LM`s leaves. However, further study is required to find out the active components which are responsible for these activities.\",\"PeriodicalId\":10410,\"journal\":{\"name\":\"Clinical Pharmacology & Biopharmaceutics\",\"volume\":\"151 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Pharmacology & Biopharmaceutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2167-065x.1000185\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Pharmacology & Biopharmaceutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2167-065x.1000185","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

摘要

研究了山苍子叶提取物的抗氧化、镇痛和止泻活性,以评价其药理活性。本研究考察了其体外抗氧化性能、体内镇痛和止泻活性。抗氧化剂通过抑制自由基,在保护人体多种疾病中发挥着重要作用。以1,1 -二苯基-2吡啶酰肼(DPPH)自由基清除能力为评价指标。研究醋酸扭体法和蓖麻油法对白化小鼠的镇痛和止泻作用。与标准抗坏血酸比较,LM叶甲醇提取物的IC50值为223.22 μg/ml。该提取物在500 mg/kg剂量下对小鼠扭体的抑制率为68.75% (p<0.001),而双氯芬酸钠标准药物的抑制率为76.25%。与洛哌丁胺(50 mg/kg)标准相比,LM还显著(P<0.01)降低了蓖麻油引起小鼠腹泻的频率。本研究明确支持了LM叶的药用价值。然而,需要进一步的研究来找出负责这些活动的有效成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Antioxidant, Analgesic and Antidiarrheal Activities of Methanolic Extract of Litsea monopetala (roxb.) Leaves
Antioxidant, analgesic and antidiarrheal activities of Litsea monopetala (LM) leaves extracts were investigated in order to assessment of pharmacological activities. In vitro antioxidant properties, in vivo analgesic and antidiarrheal activities were investigated in this study. Antioxidant plays a remarkable role to protect different kinds of diseases of human by inhibiting free radicals. 1, 1-diphenyl-2picrylhydrazyl (DPPH) free radical scavenging was considered to evaluate the antioxidant property. Analgesic and antidiarrheal activities were investigated in acetic acid induced writhing and castor oil induced antidiarrheal method by white albino mice, respectively. Methanolic extract of LM leaves has shown antioxidant activity with an IC50 value of 223.22 μg/ml which was compared to the standard ascorbic acid. This extract of LM at a dose of 500 mg/kg showed statistically significantly (p<0.001) and produced 68.75% writhing inhibition of mice while standard diclofenac sodium drug has shown 76.25% inhibition. LM also produced a significant (P<0.01) reduction in the frequency of diarrhea produced by castor oil in mice compared with Loperamide (50 mg/kg) standard. This study clearly supports the medicinal value of LM`s leaves. However, further study is required to find out the active components which are responsible for these activities.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信