{"title":"印度凤梨醇提物对实验动物的抗炎和抗伤作用","authors":"G. Sammaiah, K. Thirupathi, R. Srivastava","doi":"10.4314/ECAJPS.V10I2.9760","DOIUrl":null,"url":null,"abstract":"The alcoholic extract of Polygala arvensis (family Polygalaceae) was screened for antinociceptive and anti-inflammatory activities in experimental animals. The extract was administered for three consecutive days. Following an oral dose of 25 - 100 mg/kg, the extract exhibited graded dose response equivalent to 16.24% - 55.43% protection in the tail flick latent test in rats. Oral doses of 50 and 100 mg/kg of the extract administered to mice effectively increased reaction time in the hot plate method by 69.55% (p Keywords : Polygala arvensis , alcoholic extract, antinociceptive, anti-inflammatory East and Central African Journal of Pharmaceutical Sciences Vol. 10 (2) 2007: pp. 39-44","PeriodicalId":22387,"journal":{"name":"The East and Central African Journal of Pharmaceutical Sciences","volume":"11 1","pages":"39-44"},"PeriodicalIF":0.0000,"publicationDate":"2008-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Anti-inflammatory and Antinociceptive Effects of the Alcoholic Extract of Indian Polygala arvensis in Experimental Animals\",\"authors\":\"G. Sammaiah, K. Thirupathi, R. Srivastava\",\"doi\":\"10.4314/ECAJPS.V10I2.9760\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The alcoholic extract of Polygala arvensis (family Polygalaceae) was screened for antinociceptive and anti-inflammatory activities in experimental animals. The extract was administered for three consecutive days. Following an oral dose of 25 - 100 mg/kg, the extract exhibited graded dose response equivalent to 16.24% - 55.43% protection in the tail flick latent test in rats. Oral doses of 50 and 100 mg/kg of the extract administered to mice effectively increased reaction time in the hot plate method by 69.55% (p Keywords : Polygala arvensis , alcoholic extract, antinociceptive, anti-inflammatory East and Central African Journal of Pharmaceutical Sciences Vol. 10 (2) 2007: pp. 39-44\",\"PeriodicalId\":22387,\"journal\":{\"name\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"volume\":\"11 1\",\"pages\":\"39-44\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ECAJPS.V10I2.9760\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The East and Central African Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ECAJPS.V10I2.9760","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-inflammatory and Antinociceptive Effects of the Alcoholic Extract of Indian Polygala arvensis in Experimental Animals
The alcoholic extract of Polygala arvensis (family Polygalaceae) was screened for antinociceptive and anti-inflammatory activities in experimental animals. The extract was administered for three consecutive days. Following an oral dose of 25 - 100 mg/kg, the extract exhibited graded dose response equivalent to 16.24% - 55.43% protection in the tail flick latent test in rats. Oral doses of 50 and 100 mg/kg of the extract administered to mice effectively increased reaction time in the hot plate method by 69.55% (p Keywords : Polygala arvensis , alcoholic extract, antinociceptive, anti-inflammatory East and Central African Journal of Pharmaceutical Sciences Vol. 10 (2) 2007: pp. 39-44
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