HPV感染与上呼吸道-消化道的癌变

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Colombia Medica Pub Date : 2011-06-06 DOI:10.25100/CM.V42I2.777

Andres Castillo

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引用次数: 7

摘要

最近，分子和流行病学研究表明，人乳头瘤病毒(HPV)在女性和男性上气消化道(UADT)癌症的一个亚群中的病因学作用。通过口交获得的口腔HPV感染似乎是HPV相关口腔癌的主要危险因素。高危型HPV-16是大多数口腔癌中最常见的hpv阳性感染。因此，如果HPV-16预防疫苗被证明能够预防口腔HPV-16感染，则HPV-16预防疫苗可以预防HPV相关口腔癌。因此，这些发现为口腔癌的一级预防创造了新的潜在机会。

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HPV infection and carcinogenesis in the upper aero-digestive tract

Recently, molecular and epidemiological studies have shown an etiologic role for human papillomavirus (HPV) in a subset of upper aero-digestive tract (UADT) cancers in women and men. Oral HPV infections acquired through oral sex seems to be the main risk factor for HPV-associated oral cancers. The high-risk type HPV-16 was the most prevalent infection HPV-positive in most oral cancers. Therefore, the prophylactic vaccine against HPV-16 could prevent HPV associated oral cancer if the vaccine were demonstrated to be capable of preventing oral HPV-16 infection. Thus, these findings have created new potential opportunities for the primary prevention of oral cancers.

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来源期刊

Colombia Medica MEDICINE, GENERAL & INTERNAL-

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Colombia Médica is an international peer-reviewed medical journal that will consider any original contribution that advances or illuminates medical science or practice, or that educates to the journal''s’ readers.The journal is owned by a non-profit organization, Universidad del Valle, and serves the scientific community strictly following the International Committee of Medical Journal Editors (ICMJE) and the World Association of Medical Editors (WAME) recommendations of policies on publication ethics policies for medical journals. Colombia Médica publishes original research articles, viewpoints and reviews in all areas of medical science and clinical practice. However, Colombia Médica gives the highest priority to papers on general and internal medicine, public health and primary health care.