感染COVID-19的孕妇服用抗病毒药物的总体后果

Gamze Akpınar, Cihan Tastan
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引用次数: 1

摘要

在怀孕期间,呼吸系统的解剖结构发生变化,通过飞沫和气溶胶传播的病毒更容易被孕妇吸入,难以被清除。妇女通常更容易受到各种妊娠相关并发症和呼吸道病原体的影响,从而增加了发生不良妊娠和新生儿结局的风险。坊间证据表明,孕妇在疾病传播方面似乎与一般人群没有什么不同,迄今为止,没有证据表明存在从母亲向胎儿的垂直传播。然而,在另一项研究中,已知冠状病毒家族的成员会导致严重的并发症,如流产、胎儿生长受限和怀孕期间的先天性异常。迄今为止,只有少数研究报告了妊娠后期受SARS-CoV-2感染的妇女的不良分娩结局发生率相对较高。本文献综述介绍了用于治疗COVID-19疾病的药物在妊娠期的使用和妊娠结局。结合现有文献,探讨妊娠、分娩和产后SARS - CoV-2感染的有效控制和管理,指导卫生人员。需要进行大规模流行病学研究,以评估妊娠期感染的过程以及所使用药物对妊娠和胎儿的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Overall Consequence of Antiviral Drugs Given to Pregnant Women with COVID-19
During pregnancy, the anatomical structure of the respiratory system changes, and the virus transmitted by droplets and aerosols are more easily inhaled and difficult to remove by pregnant women. Women are generally more susceptible to various pregnancy-related complications and respiratory pathogens, increasing the risk of developing adverse pregnancy and neonatal outcomes. Anecdotal evidence suggests that pregnant women do not appear to differ from the general population in terms of disease transmission, and to date, there is no evidence of vertical transmission from mother to fetus. However, in another study, it is known that members of the coronavirus family are responsible for serious complications such as miscarriage, fetal growth restriction, and congenital anomalies during pregnancy. To date, only a few studies have reported relatively higher rates of adverse birth outcomes in women affected by SARS-CoV-2 infection in late pregnancy. This literature review presents the use of drugs used for the treatment of COVID-19 disease in pregnancy and pregnancy outcomes. It is also aimed to examine the effective control and management of SARS CoV-2 infection in the pregnancy, delivery, and postpartum period in line with the existing literature and guide health personals. Large-scale epidemiological studies are needed to evaluate the course of the infection during pregnancy and the effects of the drugs used on pregnancy and fetus.
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