高血压与COVID-19患者预后的关系:一项系统综述和荟萃分析

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-05-08 DOI:10.1080/10641963.2022.2071914

Zhe Qian, Zhuohong Li, J. Peng, Qiqing Gao, S. Cai, Xuwen Xu

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引用次数: 8

摘要

背景:探讨高血压与2019冠状病毒病(COVID-19)肺炎患者住院死亡率、重症监护病房(ICU)入院和有创通气等临床结局的关系。方法系统检索PubMed中评估感染SARS-CoV-2的高血压患者临床结局的文章。评估的主要结局包括:住院死亡率、ICU入院率和有创通气的使用。结果共纳入18项研究，13293例患者，涵盖时间为2020年1月25日至2020年4月20日。评估新冠肺炎患者高血压与预后的关系。结果显示，高血压是COVID-19患者院内死亡的危险因素(RR: 2.20, 95% CI: 1.83 ~ 2.65, P < 0.001)。此外，高血压患者更容易进入ICU (RR: 1.86, 95% CI, 1.13-3.07, P = .001)和使用有创通气(RR: 2.99, 95% CI, 1.73-5.17, P < .001)。结论在COVID-19患者中，合并高血压的患者院内死亡风险、进入ICU的风险和需要有创通气的风险均显著增加。

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Association between hypertension and prognosis of patients with COVID-19: A systematic review and meta-analysis

ABSTRACT Background To investigate the association between hypertension and clinical outcomes, including in-hospital mortality, intensive care unit (ICU) admission, and invasive ventilation in patients with coronavirus disease 2019 (COVID-19) pneumonia. Methods We implemented a systematic search of PubMed for articles that assessed clinical outcomes of hypertensive patients infected with SARS-CoV-2. The primary outcomes evaluated included: in-hospital mortality, ICU admission, and the use of invasive ventilation. Results A total of 18 studies were included, involving 13,293 patients and covering from January 25, 2020, to April 20, 2020. The relationship between hypertension and prognosis in COVID-19 patients was evaluated. Results showed that hypertension was a risk factor for in-hospital mortality in COVID-19 patients (RR: 2.20, 95% CI, 1.83–2.65, P < .001). Moreover, patients with hypertension were more likely to be admitted to ICU (RR: 1.86, 95% CI, 1.13–3.07, P = .001) and to use invasive ventilation (RR: 2.99, 95% CI, 1.73–5.17, P < .001). Conclusions Among COVID-19 patients, those combined with hypertension had a significantly higher risk of in-hospital deaths, admission to ICU, and need for invasive ventilation.

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.