{"title":"近红外光免疫治疗肿瘤细胞毒性机制研究","authors":"Kazuhide Sato","doi":"10.2530/jslsm.jslsm-41_0020","DOIUrl":null,"url":null,"abstract":"Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed next-generation cancer photo-target therapy that combines the specificity of intravenously injected antibodies for targeting tumors with toxicity induced by photoabsorber (IR700) after exposure to NIR-light. NIR-PIT is realized its multidisciplinary method with the combination of the technologies in chemistry, biolody, pharmacology and physics. Presently, NIR-PIT is under the international phase III clinical trial against locoregional, recurrent head and neck SCC (HNSCC) (LUZERA-301, NCT03769506) with FDA fast track approval and expected to be clinically licensed in a few years. However, the precise mechanism of NIR-PIT is still unknown. In this review, the scheme of NIR-PIT and the mechanism of NIR-PIT is outlined.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"32 1","pages":"104-109"},"PeriodicalIF":0.0000,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"A Mechanism of Cancer Cell Cytotoxicity of Near-Infrared Photoimmunotherapy\",\"authors\":\"Kazuhide Sato\",\"doi\":\"10.2530/jslsm.jslsm-41_0020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed next-generation cancer photo-target therapy that combines the specificity of intravenously injected antibodies for targeting tumors with toxicity induced by photoabsorber (IR700) after exposure to NIR-light. NIR-PIT is realized its multidisciplinary method with the combination of the technologies in chemistry, biolody, pharmacology and physics. Presently, NIR-PIT is under the international phase III clinical trial against locoregional, recurrent head and neck SCC (HNSCC) (LUZERA-301, NCT03769506) with FDA fast track approval and expected to be clinically licensed in a few years. However, the precise mechanism of NIR-PIT is still unknown. In this review, the scheme of NIR-PIT and the mechanism of NIR-PIT is outlined.\",\"PeriodicalId\":19350,\"journal\":{\"name\":\"Nippon Laser Igakkaishi\",\"volume\":\"32 1\",\"pages\":\"104-109\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nippon Laser Igakkaishi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2530/jslsm.jslsm-41_0020\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nippon Laser Igakkaishi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2530/jslsm.jslsm-41_0020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Mechanism of Cancer Cell Cytotoxicity of Near-Infrared Photoimmunotherapy
Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed next-generation cancer photo-target therapy that combines the specificity of intravenously injected antibodies for targeting tumors with toxicity induced by photoabsorber (IR700) after exposure to NIR-light. NIR-PIT is realized its multidisciplinary method with the combination of the technologies in chemistry, biolody, pharmacology and physics. Presently, NIR-PIT is under the international phase III clinical trial against locoregional, recurrent head and neck SCC (HNSCC) (LUZERA-301, NCT03769506) with FDA fast track approval and expected to be clinically licensed in a few years. However, the precise mechanism of NIR-PIT is still unknown. In this review, the scheme of NIR-PIT and the mechanism of NIR-PIT is outlined.
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