猪妊娠的建立及其免疫学意义。

E. Koch
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引用次数: 5

摘要

胎儿作为半同种异体移植物的考虑,由于其父亲遗传组织相容性抗原是普遍接受的。已经提出了许多假设来解释母体免疫系统对这一概念的免疫接受,但没有一种理论被证明是充分的。到目前为止,大多数研究都是在实验室啮齿动物和人身上进行的,但对农场动物,特别是猪的相应调查却很有限。由于不同物种之间存在显著差异,例如在胎盘类型、产仔数、妊娠时间和激素产生方面,因此必须确定啮齿动物和人类研究与其他物种的相关性。本综述在其他哺乳动物系统的现有信息的背景下,研究了仔猪是否表达抗原并向母体免疫系统呈递抗原,母猪对这些抗原的识别和反应程度,以及在识别的情况下,仔猪避免和利用组织不相容后果的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Establishment of pregnancy and its immunological implications in the pig.
The consideration of the fetus as a semi-allograft by virtue of its paternally inherited histocompatibility antigens is generally accepted. Many hypotheses have been put forward to explain the immunological acceptance of the conceptus by the maternal immune system, but no single theory has proved to be adequate. Most studies so far have been carried out with laboratory rodents and men but corresponding investigations of farm animals and especially the pig are limited. Because striking differences exist between various species, e.g. with respect to the type of placentation, litter size, gestation time and hormone production, the relevance of studies in rodents and men for other species has to be established. This review examines, in the context of available information from other mammalian systems, whether the pig conceptus expresses and presents antigens to the maternal immune system, to what extent the sow recognizes and responds to these antigens, and, in the event of recognition, the mechanisms by which the conceptus avoids and exploits the consequences of histoincompatibility.
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