新生儿同种免疫性血小板减少症。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-02-01 DOI:10.1046/J.1526-0968.2002.00397.X

S. Rothenberger

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引用次数: 15

摘要

新生儿同种免疫性血小板减少症(NAIT)可发生当母亲免疫胎儿血小板抗原遗传自父亲。早期诊断和适当的血小板输注治疗是必不可少的，以防止危及生命的颅内出血的血小板减少性胎儿或新生儿。五种主要的人类血小板抗原(HPA)系统能够引起这种疾病，其中HPA-1a是最常见的。本文综述了NAIT的病理生理学、临床方面和治疗。我们还介绍了我们治疗新生儿患这种疾病的经验。

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Neonatal alloimmune thrombocytopenia.

Neonatal alloimmune thrombocytopenia (NAIT) can occur when a mother is immunized against fetal platelet antigens inherited from the father. Early diagnosis and appropriate platelet transfusion therapy are essential to prevent life-threatening intracranial hemorrhage in the thrombocytopenic fetus or neonate. Five major human platelet antigen (HPA) systems are capable of causing this disorder with HPA-1a indicated most frequently. This article reviews the pathophysiology, clinical aspects, and management of NAIT. We also present our experience with treatment of neonates affected with this disorder.

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Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis

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