BMI和脂肪因子遗传变异对未治疗乳腺癌患者血清激素浓度的影响一项初步研究

IF 0.4 Q4 ONCOLOGY
Zahra Tahmasebi Fard
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引用次数: 0

摘要

背景:大量研究表明脂肪组织分泌的激素与癌症的发生有关。目的:本研究旨在探讨体重指数(BMI)和瘦素和脂联素遗传变异对未治疗乳腺癌患者血清瘦素、脂联素和雌二醇浓度的影响。方法:本病例对照研究对未服用任何药物的350名妇女(175名乳腺癌妇女和175名健康对照)进行。采用ELISA技术测定血清雌二醇(17- β雌二醇)、瘦素和脂联素水平。采用RFLP-PCR技术检测血分离DNA中瘦素基因(LepG2548A)、瘦素受体(Q223、K109R和K656N)和脂联素基因(T45G、G276T、C11377G和11391A)的单核苷酸多态性。结果:体重指数可影响血清激素浓度,并与乳腺癌相关。此外,除脂联素C11377G多态性外,其他所有遗传变异均与乳腺癌有显著关系。在两组中,BMI与平均血清激素浓度显著相关,且G2548A、Q223R、K656N和G276T多态性增加了乳腺癌的风险。危险等位基因型对血清激素浓度的影响表明,在所有研究的多态性中,血清雌激素和瘦素浓度的变化与绝经后妇女乳腺癌有关。而脂联素水平仅受K109R、K656N、G276和G11391A多态性的影响。结论:高BMI和遗传变异可通过改变不同基因型的血清激素浓度影响癌症的发展。研究不同人群的基因和生活方式有助于得出关于基因和肥胖的明确结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of BMI and Genetic Variation of Adipokines on Serum Concentrations of Hormones in Untreated Individuals with Breast Cancer; a Pilot Study
Background: Numerous studies have shown an association between hormones secreted by adipose tissues and cancer development. Objectives: This study aimed at investigating the effect of body mass index (BMI) and genetic variation of leptin and adiponectin on serum concentrations of leptin, adiponectin, and estradiol among untreated breast cancer. Methods: This case-control study was performed on 350 women (175 women with breast cancer and 175 healthy controls), who had not taken any medications. Serum levels of estradiol (17-beta estradiol), leptin, and adiponectin were measured, using the ELISA technique. Single-nucleotide polymorphisms of leptin gene (LepG2548A), leptin receptor (Q223, K109R, and K656N), and adiponectin gene (T45G, G276T, C11377G, and 11391A) in blood-isolated DNA were evaluated, using RFLP-PCR technique. Results: Body mass index can affect serum concentrations of hormones and is associated with breast cancer. Also, except for adiponectin C11377G polymorphism, other all genetic variations showed significant relationships with breast cancer. In both groups, BMI was significantly correlated with the mean serum concentrations of hormones, and the risk of breast cancer increased in G2548A, Q223R, K656N, and G276T polymorphisms. The effect of risk allele genotypes on serum concentration of hormones showed that changes in serum concentration of estrogen and leptin in all studied polymorphisms were associated with breast cancer in postmenopausal women. But adiponectin level was only affected by polymorphisms K109R, K656N, and G276 and G11391A. Conclusions: High BMI and genetic variation can affect cancer development by changing the serum concentrations of hormones in different genotypes. Studying various populations’ genetics and lifestyle can help definitive conclusions about genetics and obesity.
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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