摩洛哥产西班牙紫枝挥发油的化学成分、抗氧化/抗菌活性及ADMET研究

IF 2.2 3区农林科学 Q3 CHEMISTRY, APPLIED

Journal of Essential Oil Research Pub Date : 2023-01-28 DOI:10.1080/10412905.2023.2170483

Mustapha Cherrate, R. El-mernissi, Aziz Bouymajane, F. Filali, E. Trovato, G. Echchgadda, Abdellah Maissour, M. A. Ajana, P. Dugo, F. Cacciola, L. Mondello, K. Makroum

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引用次数: 1

摘要

摘要:本研究旨在研究摩洛哥中部地图集(Middle Atlas of Morocco, Boulmane)紫檀(Ziziphora hispanica, ZH-EO)挥发油的化学成分，评价其抗氧化和抗菌活性，并对其进行吸收、分布、代谢、排泄、毒性(ADMET)研究。结果表明，经GC-FID和GC-MS分析，共鉴定出119种挥发性成分，占ZH-EO总挥发性成分的88.7%。ZH-EO对单核增生李斯特菌、铜绿假单胞菌和粪肠球菌均有杀菌作用，对金黄色葡萄球菌有抑菌作用。ZH-EO对DPPH自由基具有较强的抗氧化活性(IC50 = 1.3 mg/mL)。ADMET预测结果表明，被试组分具有良好的药代动力学特性。本研究结果提示，西班牙紫枝挥发油具有抗氧化和抗菌活性，具有预防氧化应激相关疾病和病原菌的作用。

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Chemical composition, antioxidant/antibacterial activities and ADMET study of the essential oil isolated from the aerial parts of Ziziphora hispanica grown in Morocco

ABSTRACT The present study aimed to characterize the chemical composition and evaluate the antioxidant and antibacterial activities along with the absorption, distribution, metabolism, excretion, toxicity (ADMET) study of the essential oil of Ziziphora hispanica (ZH-EO), collected from the Middle Atlas of Morocco (Boulmane). Results showed that a total of 119 volatile components, characterized by GC-FID and GC-MS analysis, which represents the 88.7% of the total of ZH-EO. ZH-EO displayed a bactericidal effect against Listeria monocytogenes, Pseudomonas aeruginosa and Enterococcus faecalis, and a bacteriostatic effect against Staphylococcus aureus. Furthermore, ZH-EO exhibited strong antioxidant activity against DPPH radical (IC50 = 1.3 mg/mL). The ADMET prediction showed good pharmacokinetic properties of the tested components. The findings obtained from this study suggest that Ziziphora hispanica essential oil could represent a source of bioactive molecules with antioxidant and antibacterial potential in the prevention against diseases related to oxidative stress and pathogenic bacteria.

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来源期刊

Journal of Essential Oil Research 工程技术-食品科技

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

18-36 weeks

期刊介绍： Journal of Essential Oil Research ( JEOR) is the major forum for the publication of essential oil research and analysis. Each issue includes studies performed on the chemical composition of some of the 20,000 aromatic plants known in the plant kingdom. JEOR is devoted entirely to all phases of research from every corner of the world by the experts in their field. JEOR''s main areas of focus include: -Analytical chemistry- Biological activity- Biotechnology- Chemical composition- Chemical synthesis- Chemosystematics- Microbiological activity- Plant biochemistry/biosynthesis- Toxicology. Published six times per year, JEOR provides articles on the aromatic principles of a plant or its isolates and are directed toward furthering our readers'' knowledge of the aromatic plant and animal kingdoms.