肝功能的正确解读

김성은
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引用次数: 3

摘要

所有专业的医生都需要评估肝功能检查的异常结果。许多肝功能检查结果异常的患者并没有原发性肝病;大多数经常要求的检查都受到无数非肝脏因素的影响。最常见的检测是检测血清中天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)和胆红素的水平。肝细胞损伤表现为与ALP水平相比,AST和ALT水平异常升高。与AST和ALT水平相比,ALP水平异常升高表明胆汁淤积性损伤。大部分胆红素以非结合胆红素的形式循环,结合胆红素水平升高是肝细胞或胆汁淤积损伤的标志。获得详细的病史、临床检查和对肝脏检查异常结果的最佳解释,可以确定肝脏疾病的原因,促进其诊断和治疗。(韩医2019;94:89-95)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
간기능의 올바른 해석
Physicians of all specialties are required to assess abnormal results of liver function tests. Many patients with abnormal results in liver function tests do not have primary liver disease; most of the frequently requested tests are influenced by myriad non-hepatic factors. The most common tests are those for serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin. Hepatocellular injury is indicated by abnormally elevated AST and ALT levels compared to the ALP level. Cholestatic injury is indicated by an abnormally elevated ALP level compared to AST and ALT levels. The majority of bilirubin circulates as unconjugated bilirubin, and an elevated conjugated bilirubin level is a marker of hepatocellular or cholestatic injury. Obtaining a detailed medical history, a clinical examination, and optimal interpretation of abnormal results of liver tests can enable the determination of the cause of liver diseases, facilitating their diagnosis and therapy. (Korean J Med 2019;94:89-95)
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