T. Bancroft, B. Debuysscher, C. Weidle, A. Schwartz, A. Wall, M. Gray, Junli Feng, H. Steach, K. Fitzpatrick, M. Gewe, Patrick D. Skog, C. Doyle-Cooper, T. Ota, R. Strong, D. Nemazee, M. Pancera, L. Stamatatos, A. McGuire, Justin J. Taylor
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Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes
An anti-idiotype recognizing the germline version of a broadly neutralizing antibody was utilized to identify human B cells expressing similar germline antibodies and was converted to an immunogen to stimulate transgenic murine B cells in vivo despite the presence of anergy.
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