瑞士绵羊和山羊胃肠道线虫对苯并咪唑的耐药性。

IF 0.2 4区 农林科学 Q4 VETERINARY SCIENCES
H. Hertzberg, J. Rossmann, L. Kohler, U. Willi
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引用次数: 11

摘要

采用幼虫孵化试验和粪卵计数减少试验(FECRT),对瑞士20个随机选择的绵羊和山羊养殖场的胃肠道线虫(对苯并咪唑具有抗性)的发生情况进行了调查。15个养殖场(75%)检出耐苯并咪唑圆形毛癣菌。大多数养殖场的耐药程度为中高,处理后粪卵数平均减少仅66%。硫苯达唑平均浓度为0.44µg/ml(截值为0.1µg/ml)。在这13个进行了两项测试的农场中,结果是一致的。瑞士首次分离到一株对苯并咪唑耐药的弯血蜱(Haemonchus contortus), LDso为0.62µg/ml。这种寄生虫是大多数农场的主要抗性物种。尽管这项调查并不代表瑞士境内非常异质的绵羊和山羊养殖系统,但必须被归类为抗性的农场的比例令人震惊。绵羊和山羊的频繁移动很可能在很大程度上促进了抗药种群在羊群之间的传播。特别是,放牧来自不同农场和高山牧场的动物的普遍做法以及将未经处理的动物纳入新的畜群是主要的风险因素。建议在绵羊和山羊养殖场定期用FECRT检查苯并咪唑的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Benzimidazole-resistance in gastrointestinal nematodes of sheep and goats in Switzerland.
The occurrence of gastrointestinal nematodes, resi­stant against benzimidazoles, was investigated in twenty randomly selected sheep and goat farms in Switzerland using the larval hatch assay and the faecal egg count reductions test (FECRT). Benzimidazole-resistant tricho­strongyles were detected in fifteen farms (75 %). The degree of resistance was moderate to high in the majority of the farms, the mean reduction of the faecal egg counts after treatment was only 66 %. The LDso averaged at 0.44 µg/ml thiabendazole (cut off: 0.1 µg/ml). In those thirteen farms, in which both tests were carried out, the results were corresponding. A benzimidazole-resistant population of Haemonchus contortus (LDso 0.62 µg/ml) was isolated for the first time in Switzerland. This parasite was the domi­ nating resistant species in the majority of the farms. Al­though this survey is not representative for the very heterogenous sheep and goat husbandry systems in Switzer­land, the rate of farms which had to be classified as resi­stant is alarming. The frequent movements of sheep and goats most likely contribute considerably to the spread of resistant populations between flocks. In particular, the common practice of grazing animals from different farms an alpine pastures and the integration of untreated animals into new flocks represent major risk factors. lt is recom­mended, that the efficacy of benzimidazoles should be checked regularly with the FECRT in sheep and goat farms.
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来源期刊
Wiener tierarztliche Monatsschrift
Wiener tierarztliche Monatsschrift 农林科学-兽医学
CiteScore
0.40
自引率
50.00%
发文量
0
审稿时长
>36 weeks
期刊介绍: Die WTM veröffentlicht Manuskripte, die veterinärmedizinische Fragestellungen (Grundlagenforschung oder klinisch angewandte Forschung) sowie allgemeinmedizinische oder lebensmittelhygienische Fragestellungen mit veterinärmedizinischem Bezug behandeln. Eingereichte Manuskripte werden einem unabhängigen, anonymen Peer Review Verfahren unterzogen.
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