白细胞介素-6在2019冠状病毒病肺炎中的作用:炎症的敏感标志物、通气支持的预测因子和冠状病毒病后肺纤维化的早期标志物单中心体验

IF 0.2 Q4 RESPIRATORY SYSTEM
S. Patil, G. Gondhali, Abhijith G. Acharya
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Results In the study of 1000 COVID-19 pneumonia cases, age (<50 and >50 years) and sex has a significant associations with IL-6. High-resolution computed tomography severity score at entry point has significant correlation with IL-6 level (P<0.00001). IL-6 level has a significant association with duration of illness (P<0.00001) comorbidities has a significant association with IL-6 level (P<0.00001). IL-6 level has a significant association with oxygen saturation (P<0.00001). BIPAP/NIV requirement has a significant association with IL-6 level (P<0.00001). Timing of BIPAP/NIV requirement during the course of hospitalization has significant association with IL-6 level (P<0.00001). Follow-up IL-6 titer during hospitalization as compared with entry point abnormal IL-6 has a significant association in post-COVID lung fibrosis (P<0.00001). 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引用次数: 0

摘要

白细胞介素-6 (IL-6)在细菌感染中的数据可靠,现在它可以作为炎症标志物用于当前正在进行的2019冠状病毒病(COVID-19)肺炎大流行,以指导治疗策略。患者和方法前瞻性、观察性、随访12周,纳入1000例逆转录PCR确诊的COVID-19病例。对所有病例进行评估,记录肺部受累情况,并通过高分辨率胸部计算机断层扫描、血氧饱和度、进入点的IL-6和随访进行分类。年龄,性别,合并症,双水平气道正压通气/无创通气(BIPAP/NIV)的使用和结果,根据计算机断层扫描的严重程度,有无肺纤维化。统计学分析采用χ2检验。结果在1000例COVID-19肺炎病例的研究中,年龄(50岁)和性别与IL-6有显著相关性。入点高分辨率ct严重程度评分与IL-6水平有显著相关性(P<0.00001)。IL-6水平与病程有显著相关性(P<0.00001)。合并症与IL-6水平有显著相关性(P<0.00001)。IL-6水平与血氧饱和度有显著相关性(P<0.00001)。BIPAP/NIV要求与IL-6水平有显著相关性(P<0.00001)。住院期间需要BIPAP/NIV的时间与IL-6水平有显著相关性(P<0.00001)。住院期间随访IL-6滴度与入院点IL-6异常与新冠肺炎后肺纤维化有显著相关性(P<0.00001)。住院期间随访IL-6滴度与入院时正常IL-6滴度与新冠肺炎后肺纤维化有显著相关性(P<0.00001)。住院期间随访IL-6滴度与入境点异常IL-6与预测细胞因子风暴有显著相关性,无论入境点IL-6正常或异常(P<0.0001)。结论IL-6在COVID-19肺炎中具有预测病情严重程度、病情进展和“细胞因子风暴”的重要作用。序列IL-6滴度将有助于评估住院期间对治疗的反应,并分析covid后肺纤维化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of interleukin-6 in coronavirus disease 2019 pneumonia: sensitive marker of inflammation, a predictor of ventilatory support and early marker of post-coronavirus disease lung fibrosis. A single center experience
Background Robust data on interleukin-6 (IL-6) is available in bacterial infection, and now it can be utilized in the currently ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic to guide treatment strategy as a marker of inflammation. Patients and methods Prospective, observational, and 12 weeks follow-up study, included 1000 COVID-19 cases confirmed with reverse transcription PCR. All cases were assessed with lung involvement documented and categorized on high-resolution computed tomography thorax, oxygen saturation, IL-6 at the entry point, and follow-up. Age, sex, comorbidity, and bilevel positive airway pressure/noninvasive ventilation (BIPAP/NIV) use and outcome as with or without lung fibrosis as per computed tomography severity. Statistical analysis is done by χ2 test. Results In the study of 1000 COVID-19 pneumonia cases, age (<50 and >50 years) and sex has a significant associations with IL-6. High-resolution computed tomography severity score at entry point has significant correlation with IL-6 level (P<0.00001). IL-6 level has a significant association with duration of illness (P<0.00001) comorbidities has a significant association with IL-6 level (P<0.00001). IL-6 level has a significant association with oxygen saturation (P<0.00001). BIPAP/NIV requirement has a significant association with IL-6 level (P<0.00001). Timing of BIPAP/NIV requirement during the course of hospitalization has significant association with IL-6 level (P<0.00001). Follow-up IL-6 titer during hospitalization as compared with entry point abnormal IL-6 has a significant association in post-COVID lung fibrosis (P<0.00001). Follow-up IL-6 titer during hospitalization as compared with entry point normal IL-6 has a significant association in post-COVID lung fibrosis (P<0.00001). Follow-up IL-6 titer during hospitalization as compared with entry point abnormal IL-6 has a significant association in predicting cytokine storm irrespective normal or abnormal of IL-6 at entry point (P<0.0001). Conclusion IL-6 has documented a very crucial role in COVID-19 pneumonia in predicting the severity of illness, progression of illness, and ‘cytokine storm.’ Sequential IL-6 titers will help assess response to treatment during hospitalization and analyze post-COVID lung fibrosis.
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来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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