天然膳食产品在纳米医学中的作用

Heshu Sulaiman Rahman, Hemn Hassan Othman, Rasedee Abdullah, Nozlena Abdul Smad, Noorjahan Banu Alitheen
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引用次数: 0

摘要

长期以来,人们已经确定,富含新鲜水果、蔬菜、种子、谷物和豆类以及抗氧化剂和其他有益化合物的饮食可能有助于预防各种人类疾病。然而,饮食不是治疗严重疾病的良药,但它可能有助于预防一些疾病,它可以帮助身体克服传统治疗的影响。天然化合物不仅可以作为药物或药物模板,而且在许多情况下,也是发现新生物学的来源,为更好地了解疾病过程中涉及的靶点和途径提供了帮助。此外,从天然化合物中提取的药物比合成药物对患者的效果更好。大约40%的药物和70%的合成治疗分子存在溶解度、口服生物利用度和给药能力差的问题。溶解度较差的药物在口服给药过程中由于肠道和血管之间的浓度梯度较低而运输受限。为了提高难溶性药物的体液饱和溶解度,需要开发利用天然膳食植物代谢物的新给药方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Natural Dietary Products in Nanomedicine
It has long been established that a diet rich in fresh fruits, vegetables, seeds, grains and legumes and antioxidants, and other beneficial compounds may help prevent vari ous human diseases. However, diet is not a cure for treatment of severe diseases, but it may help prevent some ailments, and it can help the body overcome the effects of conventional treatments. Natural compounds not only serve as a drug or template for drugs but also, in many instances, had been a source of discovery of novel biology that provided better understanding of target and pathway involved in the disease processes. In addition, drugs derived from natural compounds work better for patients than do drugs manufactured synthetically. Approximately, 40% of drugs in the pipeline and 70% of synthetic therapeutic molecules are plagued with poor solubility, oral bioavailability, and delivery. Drugs with poor solubility encounter limited transport during oral admin - istration because of low concentration gradient between the gut and the blood vessels. To increase body fluid saturation solubility of poorly soluble drug, new delivery methods need to be developed using natural dietary plant metabolites.
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