白茅提取物的肝酶作用

M. Nwokike, S. Ghasi, E. C. Ogbuagu, M. N. Ezenwaeze, Akpotu E. Ajirioghene
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摘要

本研究探讨白茅根提取物对四氧嘧啶诱导的糖尿病雄性Wistar大鼠肝酶水平的影响。48只雄性wistar大鼠分为6组,每组8只。采用腹腔注射四氧嘧啶150 mg/kg体重诱导糖尿病,治疗28 d。第一组为正常对照组,仅随意饲喂饲料和水。第二组为未加提取物治疗的糖尿病大鼠。第三组:白茅根提取液200 mg/kg治疗糖尿病大鼠。第四组:白茅根水提液400mg/kg治疗糖尿病大鼠。5组:白茅根水提物乙醇提取物600mg/kg治疗糖尿病大鼠。第6组为糖尿病大鼠,给予0.5mg/kg格列本脲。四氧嘧啶(150mg/kg b.w)处理大鼠肝酶丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶水平显著(p < 0.05)变化,各剂量四氧嘧啶提取物处理大鼠肝酶水平均显著(p < 0.05)恢复正常。结果表明,不同剂量白茅根水提物对四氧嘧啶引起的雄性wistar大鼠肝脏损伤有一定的修复作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hepatic Enzyme Effects of an Imperata cylindrica Extract
This study was performed to investigate the effects of aqueous Imperata cylindrica root extract on hepatic enzyme levels of alloxan-induced diabetic male Wistar rats. Forty (48) male wistar rats were divided into six groups consisting of eight animals each. Diabetes mellitus was induced using intraperitoneal administration 150 mg/kg body weight of alloxan and treatment was carried out for a period of 28 days. The first group served as the normal control and received only feed and water ad libitum. In Group 2 were diabetic rats without treatment with extracts. Group 3: diabetic rats treated with 200 mg/kg aqueous Imperata cylindrica root extract. Group 4: diabetic rats treated with 400mg/kg aqueous Imperata cylindrica root extract. Group 5: diabetic rats treated with 600mg/kg ethanol extract of aqueous Imperata cylindrica root extract. While Group 6 was diabetic rats treated with 0.5mg/kg Glibenclamide. The liver enzymes alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels were significantly (p < 0.05) changed in rats treated with Alloxan (150mg/kg b.w.) while treatment with the respective dosages of extracts significantly changed the levels of these parameters to normal. The results obtained indicate that the different doses of aqueous Imperata cylindrica root extracts were beneficial in mending damages to the liver caused by Alloxan monohydrate in the male wistar rats.
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