{"title":"聚乙二醇(peg-400):一种高效的绿色反应介质，用于3,4 -二羟基噻吩- 2,5 -二羧酸酯或其碱金属或碱土金属盐的烷基化。","authors":"N. M. Rao","doi":"10.20959/WJPR201711-9650","DOIUrl":null,"url":null,"abstract":"The present invention relates to an improved process for the alkylation of 3, 4dihydroxythiophene-2, 5-dicarboxylic esters or their alkali metal or alkaline earth metal salts with alkylating agent and base in the presence of a solvent and catalyst PEG-400 was used as a Phase transfer Catalyst and could effectively catalyze the Reaction.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"418 1","pages":"1003-1009"},"PeriodicalIF":0.0000,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"POLYETHYLENE GLYCOL (PEG-400): AN EFFICIENT GREEN REACTION MEDIUM FOR THE ALKYLATION OF 3, 4-DIHYDROXY THIOPHENE-2, 5-DICARBOXYLIC ESTERS OR THEIR ALKALI METAL OR ALKALINE EARTH METAL SALTS.\",\"authors\":\"N. M. Rao\",\"doi\":\"10.20959/WJPR201711-9650\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present invention relates to an improved process for the alkylation of 3, 4dihydroxythiophene-2, 5-dicarboxylic esters or their alkali metal or alkaline earth metal salts with alkylating agent and base in the presence of a solvent and catalyst PEG-400 was used as a Phase transfer Catalyst and could effectively catalyze the Reaction.\",\"PeriodicalId\":23796,\"journal\":{\"name\":\"World journal of pharmaceutical research\",\"volume\":\"418 1\",\"pages\":\"1003-1009\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of pharmaceutical research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20959/WJPR201711-9650\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of pharmaceutical research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20959/WJPR201711-9650","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
POLYETHYLENE GLYCOL (PEG-400): AN EFFICIENT GREEN REACTION MEDIUM FOR THE ALKYLATION OF 3, 4-DIHYDROXY THIOPHENE-2, 5-DICARBOXYLIC ESTERS OR THEIR ALKALI METAL OR ALKALINE EARTH METAL SALTS.
The present invention relates to an improved process for the alkylation of 3, 4dihydroxythiophene-2, 5-dicarboxylic esters or their alkali metal or alkaline earth metal salts with alkylating agent and base in the presence of a solvent and catalyst PEG-400 was used as a Phase transfer Catalyst and could effectively catalyze the Reaction.
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