经鼻给予培养间充质干细胞的条件培养基可改善嗅球切除小鼠的认知障碍

K. Kojima, I. Kawahata, Hisanao Izumi, Sei-Ichi Yoshihara, K. Oki, K. Fukunaga
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引用次数: 2

摘要

阿尔茨海默病(AD)是痴呆的常见病因,表现为淀粉样蛋白-β (Aβ)积聚和胆碱能神经元变性等神经病变。嗅球切除(OBX)小鼠表现出阿尔茨海默病的一些特征,因此被用作阿尔茨海默病的研究模型。间充质干细胞(MSCs)可以分化为多种细胞,包括神经细胞。在这项研究中,我们鼻内注射了从培养脐带(UC)间充质干细胞中提取的条件培养基。鼻内给予MSCs培养基可恢复OBX小鼠的认知损伤。此外,条件培养基可恢复大鼠中隔胆碱乙酰转移酶阳性细胞数量的减少。综上所述,mscs衍生的条件培养基可能对中隔胆碱能神经元具有保护作用,从而挽救OBX的认知功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intranasal Administration of Conditioned Medium from Cultured Mesenchymal Stem Cells Improves Cognitive Impairment in Olfactory Bulbectomized Mice
Alzheimer’s disease (AD) is the common cause of dementia which shows the neuro-pathologies like an accumulation of amyloid-β (Aβ) and degeneration of cholinergic neuron. Olfactory bulbectomized (OBX) mice show some of AD features, so they have been used to research as AD model. Mesenchymal stem cells (MSCs) can differentiate into many kinds of cells, including neuronal cells. In this study, we intranasally administrated the conditioned medium derived from cultured umbilical cord (UC) MSCs. The intranasal administration of the MSCs medium restored the cognitive impairment observed in OBX mice. In addition, the decreased number of choline acetyltransferase-positive cells in the medial septum was restored by the conditioned medium administration. In conclusion, MSCs-derived conditioned medium may have protective effects of cholinergic neurons in the medial septum, thereby rescuing the cognitive impairment of OBX.
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