孟加拉产毛茛地上部抗氧化及细胞毒活性评价

Dhaka University Journal of Pharmaceutical Sciences Pub Date : 2019-09-22 DOI:10.3329/dujps.v18i2.43264

Suvash Chandra Roy, Bk Sajeeb, Abdul Muhit, S. C. Bachar

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引用次数: 3

摘要

本研究对黄连地上部甲醇提取物及其不同溶剂组分的抗氧化活性和细胞毒活性进行了研究。采用2,2′-二苯基-1-苦味酰肼(DPPH)自由基评价其体外抗氧化活性。结果表明，与阳性对照抗坏血酸(IC50 = 1.34 μg/ml)相比，乙酸乙酯可溶性组分对DPPH自由基的清除能力最高，IC50值为1.05 μg/ml。此外，以5-氟尿嘧啶为阳性对照，进行了毛毛草提取物及其不同组分对HELA细胞株的体外细胞毒性试验。结果表明，乙酸乙酯和正己烷可溶性部分具有显著的细胞毒性，IC50值分别为5.68 μg/ml和17.15 μg/ml。本研究证实，产自孟加拉国的毛茛地上部甲醇提取物乙酸乙酯可溶部位具有较强的抗氧化活性和细胞毒活性，表明其提取物中存在生物活性成分。达卡大学药学院。科学通报，18(2):217-222,2019 (12)

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Evaluation of Antioxidant and Cytotoxic Activities of Aerial Parts of Adiantum capillus-veneris L. Growing in Bangladesh

The present study evaluated the antioxidant and cytotoxic activities of methanolic extract of aerial parts of Adiantum capillus-veneris L. and its different solvent fractions. The in vitro antioxidant activity was assessed by using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals. The analysis revealed that ethyl acetate soluble fraction had the highest DPPH radicals scavenging property with IC50 value of 1.05 μg/ml as compared to positive control ascorbic acid (IC50 = 1.34 μg/ml). In addition, ex vivo cytotoxicity assay of A. capillus-veneris L. extract and its different fractions were performed against HELA cells line where 5-Fluorouracil was used as positive control. The result demonstrated that ethyl acetate and n-hexane soluble fractions showed prominent cytotoxicity with IC50 value of 5.68 μg/ml and 17.15 μg/ml, respectively. The study affirmed that superior antioxidant and cytotoxic activities were shown by ethyl acetate soluble fraction of methanolic extract of aerial parts of A. capillus-veneris L. growing in Bangladesh which indicate the presence of bioactive phytoconstituents in the extractives. Dhaka Univ. J. Pharm. Sci. 18(2): 217-222, 2019 (December)

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Dhaka University Journal of Pharmaceutical Sciences

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