D. Hartanto, Ellen Lydia Kurniasari, Ribka Artha Maria, Puspa Sari Dewi, Vina Septiani
{"title":"柠檬皮乙醇的潜在提取物(柑橘皮)。作为Wistar鼠标高糖焦虑症的替代方法","authors":"D. Hartanto, Ellen Lydia Kurniasari, Ribka Artha Maria, Puspa Sari Dewi, Vina Septiani","doi":"10.26874/KJIF.V6I2.156","DOIUrl":null,"url":null,"abstract":"<p align=\"center\"><strong>Abstrak</strong></p><p align=\"center\"><strong> </strong></p><p>Jeruk lemon (<em>Citrus limon </em>L) secara empiris telah digunakan masyarakat untuk menurunkan berat badan. Selain itu perasan jeruk lemon pun dipercaya mampu menurunkan kadar kolesterol darah. Penelitian ini bertujuan untuk menentukan potensi ekstrak etanol kulit jeruk lemon sebagai obat alternatif hiperkolesterolemia pada tikus <em>wistar</em> hiperglikemia dengan menggunakan metode proteksi. Proses ekstraksi kulit buah jeruk lemon dilakukan dengan metode maserasi. Semua tikus diberi sediaan uji sesuai dengan kelompoknya (kontrol, ekstrak etanol jeruk lemon, pembanding simvastatin) bersamaan dengan intervensi fruktosa 60% yang dicampur dalam makanannya selama 6 minggu. Pemeriksaan kadar kolesterol total dilakukan setiap minggu. Hasil pengujian menunjukkan bahwa ekstrak etanol kulit buah lemon mampu menghambat peningkatan kadar kolesterol total tikus <em>wistar </em>hiperglikemia. Ekstrak etanol kulit buah lemon dosis 70 mg/kg bb menunjukkan hasil terbaik yang berbeda bermakna dibanding kelompok kontrol (p<0,05) pada penelitian ini. Dengan demikian, ekstrak etanol kulit jeruk lemon berpotensi untuk digunakan sebagai obat alternatif hiperkolesterolemia.</p><p> </p><p><strong>Kata Kunci :</strong> Hiperkolesterolemia, Lemon, Fruktosa 60%</p><p> </p><p align=\"center\"><strong><em>Potency of lemon peel ethanolic extract (Citrus limon L.) as alternative drug for hypercholesterolemia in hyperglycemic wistar rat</em></strong></p><p><em> </em></p><p align=\"center\"><strong><em>Abstract </em></strong></p><p align=\"center\"><strong><em> </em></strong></p><p><em>Lemon (Citrus limon L) empirically has been used by the community to lose weight. Besides lemon juice is also believed to be able to reduce blood cholesterol levels. This study aims to determine the potential of ethanol extract of lemon peel as an alternative medicine for hypercholesterolemia in hyperglycemic wistar rats using the protection method. The process of extracting lemon peel is done by maceration method. All rats were given a test preparation according to their group (control, lemon ethanol extract, compared to simvastatin) together with intervention of fructose 60% mixed in the food for 6 weeks. Examination of total cholesterol levels is carried out every week. The test results showed that the ethanol extract of lemon peel was able to inhibit the increase of total cholesterol levels in hyperglycemic wistar rats. The ethanol extract of lemon peel doses of 70 mg / kg bw showed the best results which were significantly different than the control group (p <0.05) in this study. Thus, the ethanol extract of lemon peel has the potential to be used as an alternative drug for hypercholesterolemia.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em> : Hypercholesterolemia, Lemon, Fructose 60 % </em></p>","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"404 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Potensi Ekstrak Etanol Kulit Jeruk Lemon (Citrus limon L.) Sebagai Obat Alternatif Hiperkolesterolemia Pada Tikus Wistar Hiperglikemik\",\"authors\":\"D. Hartanto, Ellen Lydia Kurniasari, Ribka Artha Maria, Puspa Sari Dewi, Vina Septiani\",\"doi\":\"10.26874/KJIF.V6I2.156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p align=\\\"center\\\"><strong>Abstrak</strong></p><p align=\\\"center\\\"><strong> </strong></p><p>Jeruk lemon (<em>Citrus limon </em>L) secara empiris telah digunakan masyarakat untuk menurunkan berat badan. Selain itu perasan jeruk lemon pun dipercaya mampu menurunkan kadar kolesterol darah. Penelitian ini bertujuan untuk menentukan potensi ekstrak etanol kulit jeruk lemon sebagai obat alternatif hiperkolesterolemia pada tikus <em>wistar</em> hiperglikemia dengan menggunakan metode proteksi. Proses ekstraksi kulit buah jeruk lemon dilakukan dengan metode maserasi. Semua tikus diberi sediaan uji sesuai dengan kelompoknya (kontrol, ekstrak etanol jeruk lemon, pembanding simvastatin) bersamaan dengan intervensi fruktosa 60% yang dicampur dalam makanannya selama 6 minggu. Pemeriksaan kadar kolesterol total dilakukan setiap minggu. Hasil pengujian menunjukkan bahwa ekstrak etanol kulit buah lemon mampu menghambat peningkatan kadar kolesterol total tikus <em>wistar </em>hiperglikemia. Ekstrak etanol kulit buah lemon dosis 70 mg/kg bb menunjukkan hasil terbaik yang berbeda bermakna dibanding kelompok kontrol (p<0,05) pada penelitian ini. Dengan demikian, ekstrak etanol kulit jeruk lemon berpotensi untuk digunakan sebagai obat alternatif hiperkolesterolemia.</p><p> </p><p><strong>Kata Kunci :</strong> Hiperkolesterolemia, Lemon, Fruktosa 60%</p><p> </p><p align=\\\"center\\\"><strong><em>Potency of lemon peel ethanolic extract (Citrus limon L.) as alternative drug for hypercholesterolemia in hyperglycemic wistar rat</em></strong></p><p><em> </em></p><p align=\\\"center\\\"><strong><em>Abstract </em></strong></p><p align=\\\"center\\\"><strong><em> </em></strong></p><p><em>Lemon (Citrus limon L) empirically has been used by the community to lose weight. Besides lemon juice is also believed to be able to reduce blood cholesterol levels. This study aims to determine the potential of ethanol extract of lemon peel as an alternative medicine for hypercholesterolemia in hyperglycemic wistar rats using the protection method. The process of extracting lemon peel is done by maceration method. All rats were given a test preparation according to their group (control, lemon ethanol extract, compared to simvastatin) together with intervention of fructose 60% mixed in the food for 6 weeks. Examination of total cholesterol levels is carried out every week. The test results showed that the ethanol extract of lemon peel was able to inhibit the increase of total cholesterol levels in hyperglycemic wistar rats. The ethanol extract of lemon peel doses of 70 mg / kg bw showed the best results which were significantly different than the control group (p <0.05) in this study. Thus, the ethanol extract of lemon peel has the potential to be used as an alternative drug for hypercholesterolemia.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em> : Hypercholesterolemia, Lemon, Fructose 60 % </em></p>\",\"PeriodicalId\":32369,\"journal\":{\"name\":\"Kartika Jurnal Ilmiah Farmasi\",\"volume\":\"404 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kartika Jurnal Ilmiah Farmasi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26874/KJIF.V6I2.156\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kartika Jurnal Ilmiah Farmasi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26874/KJIF.V6I2.156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
柠檬皮(Citrus limon L)在经验上被用来减肥。此外，柠檬汁被认为可以降低血液胆固醇。这项研究的目的是确定柠檬皮乙醇提取物的潜力，作为紫红色鼠高血糖的替代药物。柠檬皮的提取是用人造的方法进行的。所有的老鼠都得到了适当的剂型(对照，柠檬乙醇乙醇提取物，simvastatin)，以及60%的果糖干预，在食物中混合了6周。胆固醇水平检查每周进行。测试结果表明，柠檬果皮乙醇的提取物可以抑制树鼠总胆固醇水平的高血糖。乙醇提取物柠檬果皮70 mg / kg剂量最好的bb显示了不同的意义比对照组(p关键词:Hiperkolesterolemia皮尔,柠檬,柠檬的果糖60% Potency ethanolic extract(柠檬柑橘L .)美国另类为hypercholesterolemia毒品在hyperglycemic wistar哀抽象柠檬(柠檬柑橘L) empirically已经过去:减肥的社区。此外，柠檬汁还被认为可以在血液选择的水平上减少。这项研究旨在确定柠檬皮的乙醇借鉴，即高血糖、乐观老鼠使用保护方法的替代药物。提取柠檬皮的过程由macertion方法完成。所有的鼠都接受了对组进行的准备测试，包括60%的水果混合物，加入食物6周。cholesterol的总偏移率每周都被削减。结果表明，柠檬皮的乙醇extract of lemon peel可能会使甲醇的总胆固醇水平增加。柠檬释放的乙醇释放了70毫克/公斤的果糖，其有效程度与控制小组不同
Potensi Ekstrak Etanol Kulit Jeruk Lemon (Citrus limon L.) Sebagai Obat Alternatif Hiperkolesterolemia Pada Tikus Wistar Hiperglikemik
Abstrak
Jeruk lemon (Citrus limon L) secara empiris telah digunakan masyarakat untuk menurunkan berat badan. Selain itu perasan jeruk lemon pun dipercaya mampu menurunkan kadar kolesterol darah. Penelitian ini bertujuan untuk menentukan potensi ekstrak etanol kulit jeruk lemon sebagai obat alternatif hiperkolesterolemia pada tikus wistar hiperglikemia dengan menggunakan metode proteksi. Proses ekstraksi kulit buah jeruk lemon dilakukan dengan metode maserasi. Semua tikus diberi sediaan uji sesuai dengan kelompoknya (kontrol, ekstrak etanol jeruk lemon, pembanding simvastatin) bersamaan dengan intervensi fruktosa 60% yang dicampur dalam makanannya selama 6 minggu. Pemeriksaan kadar kolesterol total dilakukan setiap minggu. Hasil pengujian menunjukkan bahwa ekstrak etanol kulit buah lemon mampu menghambat peningkatan kadar kolesterol total tikus wistar hiperglikemia. Ekstrak etanol kulit buah lemon dosis 70 mg/kg bb menunjukkan hasil terbaik yang berbeda bermakna dibanding kelompok kontrol (p<0,05) pada penelitian ini. Dengan demikian, ekstrak etanol kulit jeruk lemon berpotensi untuk digunakan sebagai obat alternatif hiperkolesterolemia.
Kata Kunci : Hiperkolesterolemia, Lemon, Fruktosa 60%
Potency of lemon peel ethanolic extract (Citrus limon L.) as alternative drug for hypercholesterolemia in hyperglycemic wistar rat
Abstract
Lemon (Citrus limon L) empirically has been used by the community to lose weight. Besides lemon juice is also believed to be able to reduce blood cholesterol levels. This study aims to determine the potential of ethanol extract of lemon peel as an alternative medicine for hypercholesterolemia in hyperglycemic wistar rats using the protection method. The process of extracting lemon peel is done by maceration method. All rats were given a test preparation according to their group (control, lemon ethanol extract, compared to simvastatin) together with intervention of fructose 60% mixed in the food for 6 weeks. Examination of total cholesterol levels is carried out every week. The test results showed that the ethanol extract of lemon peel was able to inhibit the increase of total cholesterol levels in hyperglycemic wistar rats. The ethanol extract of lemon peel doses of 70 mg / kg bw showed the best results which were significantly different than the control group (p <0.05) in this study. Thus, the ethanol extract of lemon peel has the potential to be used as an alternative drug for hypercholesterolemia.
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