{"title":"卡拉胶/聚乙烯醇薄膜吸湿、透湿及释药性能研究","authors":"S. Bajpai, P. Dehariya, S. S. Saggu","doi":"10.15228/2014.V04.I03.P07","DOIUrl":null,"url":null,"abstract":"* S. K. Bajpai, P. Dehariya and S. P. S. Saggu * Polymer Research Laboratory, Department of Chemistry, Govt. Model Science College, Jabalpur (M.P) – 482001, India. Email: * sunil.mnlbpi@gmail.com ABSTRACT This work describes moisture sorption behavior and water vapor permeability of gluteraldehyde –crosslinked Carrageenen/polyvinyl alcohol (Carr/PVA) films. The moisture uptake has been studied under various relative humidity (RH) and the data obtained has been interpreted in the terms of various isotherm models such as GAB, Oswin and Halsey models. The moisture permeability through the films has been characterized in the terms of various parameters like water vapor transmission rate (WVTR), permeance (P) and Water vapor permeability (WVP). It was found that these parameters are greatly affected by the degree of crosslinking of the films. Finally, the model drug Gentamycin Sulphate was loaded in to the films and its release was monitored kinetically in the physiological buffer (PF) at 37C. The films exhibited diffusion controlled release mechanism.","PeriodicalId":19815,"journal":{"name":"Pakistan Journal of Chemistry","volume":"69 1","pages":"142-152"},"PeriodicalIF":0.0000,"publicationDate":"2014-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Investigation of Moisture Sorption, Permeability and Drug Release Behavior of Carrageenan/Poly Vinyl Alcohol Films\",\"authors\":\"S. Bajpai, P. Dehariya, S. S. Saggu\",\"doi\":\"10.15228/2014.V04.I03.P07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"* S. K. Bajpai, P. Dehariya and S. P. S. Saggu * Polymer Research Laboratory, Department of Chemistry, Govt. Model Science College, Jabalpur (M.P) – 482001, India. Email: * sunil.mnlbpi@gmail.com ABSTRACT This work describes moisture sorption behavior and water vapor permeability of gluteraldehyde –crosslinked Carrageenen/polyvinyl alcohol (Carr/PVA) films. The moisture uptake has been studied under various relative humidity (RH) and the data obtained has been interpreted in the terms of various isotherm models such as GAB, Oswin and Halsey models. The moisture permeability through the films has been characterized in the terms of various parameters like water vapor transmission rate (WVTR), permeance (P) and Water vapor permeability (WVP). It was found that these parameters are greatly affected by the degree of crosslinking of the films. Finally, the model drug Gentamycin Sulphate was loaded in to the films and its release was monitored kinetically in the physiological buffer (PF) at 37C. The films exhibited diffusion controlled release mechanism.\",\"PeriodicalId\":19815,\"journal\":{\"name\":\"Pakistan Journal of Chemistry\",\"volume\":\"69 1\",\"pages\":\"142-152\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15228/2014.V04.I03.P07\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15228/2014.V04.I03.P07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
摘要
* S. K. Bajpai, P. Dehariya和S. P. S. S. Saggu *聚合物研究实验室，政府模型科学学院化学系，印度贾巴尔普尔(M.P) - 482001。摘要本文研究了谷戊醛交联卡拉胶/聚乙烯醇(Carr/PVA)薄膜的吸湿性能和透气性。研究了不同相对湿度(RH)条件下的水分吸收量，并用GAB、Oswin和Halsey等不同的等温线模式对所得数据进行了解释。通过水蒸气透过率(WVTR)、透湿率(P)和水蒸气透湿率(WVP)等参数对膜的透湿性进行表征。研究发现，这些参数受薄膜交联程度的影响较大。最后，将模型药物硫酸庆大霉素装入膜中，并在37℃的生理缓冲液(PF)中动态监测其释放。膜具有扩散控制释放机制。
Investigation of Moisture Sorption, Permeability and Drug Release Behavior of Carrageenan/Poly Vinyl Alcohol Films
* S. K. Bajpai, P. Dehariya and S. P. S. Saggu * Polymer Research Laboratory, Department of Chemistry, Govt. Model Science College, Jabalpur (M.P) – 482001, India. Email: * sunil.mnlbpi@gmail.com ABSTRACT This work describes moisture sorption behavior and water vapor permeability of gluteraldehyde –crosslinked Carrageenen/polyvinyl alcohol (Carr/PVA) films. The moisture uptake has been studied under various relative humidity (RH) and the data obtained has been interpreted in the terms of various isotherm models such as GAB, Oswin and Halsey models. The moisture permeability through the films has been characterized in the terms of various parameters like water vapor transmission rate (WVTR), permeance (P) and Water vapor permeability (WVP). It was found that these parameters are greatly affected by the degree of crosslinking of the films. Finally, the model drug Gentamycin Sulphate was loaded in to the films and its release was monitored kinetically in the physiological buffer (PF) at 37C. The films exhibited diffusion controlled release mechanism.
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