{"title":"硝基尼和阿苯达唑对家兔的不良反应","authors":"E. Elalfy, Azza Hassan, M. Amer","doi":"10.21608/mvmj.2021.215026","DOIUrl":null,"url":null,"abstract":"Correspondence to: Eman Mohammed; Tel: +201099443698; Email: alfy79@gmail.com emanel Objective: The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1, 7 and 14 days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results: The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"90 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adverse effect of Nitroxynil and Albendazole on rabbits\",\"authors\":\"E. Elalfy, Azza Hassan, M. Amer\",\"doi\":\"10.21608/mvmj.2021.215026\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Correspondence to: Eman Mohammed; Tel: +201099443698; Email: alfy79@gmail.com emanel Objective: The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1, 7 and 14 days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results: The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A.\",\"PeriodicalId\":18173,\"journal\":{\"name\":\"Mansoura Veterinary Medical Journal\",\"volume\":\"90 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mansoura Veterinary Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/mvmj.2021.215026\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mansoura Veterinary Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/mvmj.2021.215026","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
通信对象:Eman Mohammed;电话:+ 201099443698;Email: alfy79@gmail.com emanel目的:探讨兔皮下注射硝基尼和口服阿苯达唑可能产生的不良反应。设计:随机对照实验研究。实验动物:18只体重为1.50±0.5 kg的新西兰兔，随机分为3组(n=6)。方法:A组为对照组，B组口服阿苯达唑(20mg /kg B. wt.)， C组皮下注射硝基腈(10mg /kg B. wt.)。分别于给药后第1、7、14天采血进行血液学和生化检测。并对肝、肾、肠标本进行组织病理学检查。结果:与a组相比，B、C组红细胞、PCV、Hb、白细胞、淋巴细胞、中性粒细胞、谷胱甘肽、过氧化氢酶显著降低;与a组相比，B、C组血清ALT、AST、尿素、肌酐、MDA显著升高(P≤0.05)。
Adverse effect of Nitroxynil and Albendazole on rabbits
Correspondence to: Eman Mohammed; Tel: +201099443698; Email: alfy79@gmail.com emanel Objective: The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1, 7 and 14 days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results: The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A.
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