State of the antioxidant protection system in trauma patients during prolonged immobilization

BACKGROUND: The study of antioxidant protection state is important both for diagnosing the influence of forced hypodynamia on the main pathological process and development of the approaches to minimize these adverse manifestations. AIM: To study the state of antioxidant protection system in blood plasma and erythrocytes in the patients with tibia and femur fractures depending on the duration of immobilization. MATERIALS AND METHODS: The study involves biochemical examination of 20 patients with shin and hip fractures aged from 18 to 50 years, without a concomitant pathology, who underwent skeletal traction associated with prolonged restriction of motor activity. Blood sampling was performed on the 7th, 14th, 21st, 28th, and 35th days after injury. The main parameters of the antioxidant defense system in the blood plasma and erythrocytes have been studied. RESULTS: A stagewise shift of the studied parameters depending on the time of immobilization has been established. The maximum decrease in the antioxidant defense action has been noted on the 21th day, while relative stabilization of the indicators has been noted on the 35th day of the observation. CONCLUSIONS: The findings can be recommended to estimate the effect of forced limitation of motor activity on the posttraumatic process. The necessity of including vitamins with antioxidant action in the complex therapy of the patients of the corresponding profile has been proved.