{"title":"基于表位的多变体SARS-Cov-2疫苗设计:与人白细胞抗原(HLA)ⅱ类分子高硅结合亲和力的天然SARS-Cov-2刺突糖蛋白及其5种变体(D614G、α、β、γ、δ)共享表位","authors":"Spyros A. Charonis, A. Georgopoulos","doi":"10.29245/2578-3009/2021/4.1223","DOIUrl":null,"url":null,"abstract":"Page 9 of 14 Epitope-based Multi-variant SARS-Cov-2 Vaccine Design: Shared Epitopes Among the Natural SARS-Cov-2 Spike Glycoprotein and 5 of its Variants (D614G, α, β, γ, δ) with High in Silico Binding Affinity to Human Leukocyte Antigen (HLA) Class II Molecules Spyros A. Charonis1,2, Apostolos P. Georgopoulos1,2* 1The HLA SARS-CoV-2 Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN 55417, USA 2Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":"689 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Epitope-based Multi-variant SARS-Cov-2 Vaccine Design: Shared Epitopes Among the Natural SARS-Cov-2 Spike Glycoprotein and 5 of its Variants (D614G, α, β, γ, δ) with High in Silico Binding Affinity to Human Leukocyte Antigen (HLA) Class II Molecules\",\"authors\":\"Spyros A. Charonis, A. Georgopoulos\",\"doi\":\"10.29245/2578-3009/2021/4.1223\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Page 9 of 14 Epitope-based Multi-variant SARS-Cov-2 Vaccine Design: Shared Epitopes Among the Natural SARS-Cov-2 Spike Glycoprotein and 5 of its Variants (D614G, α, β, γ, δ) with High in Silico Binding Affinity to Human Leukocyte Antigen (HLA) Class II Molecules Spyros A. Charonis1,2, Apostolos P. Georgopoulos1,2* 1The HLA SARS-CoV-2 Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN 55417, USA 2Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA\",\"PeriodicalId\":73785,\"journal\":{\"name\":\"Journal of immunological sciences\",\"volume\":\"689 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of immunological sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29245/2578-3009/2021/4.1223\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of immunological sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29245/2578-3009/2021/4.1223","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
基于表位的SARS-Cov-2多变体疫苗设计天然SARS-Cov-2长链糖蛋白及其变体(D614G、α、β、γ、δ)与人类白细胞抗原(HLA)ⅱ类分子高硅基结合亲和力的共同表位Spyros A. charonis1,2, Apostolos P. Georgopoulos1,2* 1 HLA - cov -2研究组,退伍军人事务部卫生保健系统脑科学中心,明尼阿波利斯,MN 55417,美国2明尼苏达大学医学院神经学系,明尼阿波利斯,MN 55455,美国
Epitope-based Multi-variant SARS-Cov-2 Vaccine Design: Shared Epitopes Among the Natural SARS-Cov-2 Spike Glycoprotein and 5 of its Variants (D614G, α, β, γ, δ) with High in Silico Binding Affinity to Human Leukocyte Antigen (HLA) Class II Molecules
Page 9 of 14 Epitope-based Multi-variant SARS-Cov-2 Vaccine Design: Shared Epitopes Among the Natural SARS-Cov-2 Spike Glycoprotein and 5 of its Variants (D614G, α, β, γ, δ) with High in Silico Binding Affinity to Human Leukocyte Antigen (HLA) Class II Molecules Spyros A. Charonis1,2, Apostolos P. Georgopoulos1,2* 1The HLA SARS-CoV-2 Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN 55417, USA 2Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA