基质金属蛋白酶反应纳米探针在癌症诊断和治疗中的研究进展

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Reviews in Analytical Chemistry Pub Date : 2022-01-01 DOI:10.1515/revac-2022-0044

Qiuye Wang, Hai-Bin Cui, Ning Gan, Xuehua Ma, Wenzhi Ren, Aiguo Wu

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引用次数: 1

摘要

基质金属蛋白酶(Matrix metalloproteinases, MMPs)是一类含锌的内肽酶，与肿瘤的生长、浸润、转移和血管生成密切相关。通过特异性酶解，MMPs已被广泛用于开启精心设计的酶反应纳米探针的成像和/或治疗功能，有望实现癌症的精确诊断和治疗。本文系统地综述了MMPs的分类、底物和识别序列以及过表达的肿瘤类型。综述了mmp反应性纳米探针在癌症诊断和治疗中的研究进展，包括触发机制、设计原理和各种成像或治疗模式。最后，本文分析了mmp反应性纳米探针在临床应用中面临的挑战，并对未来的研究提出了建设性的意见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy

Abstract Matrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue of the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function of elaborately designed enzyme-responsive nanoprobes, which is expected to realize precise diagnosis and treatment of cancer. This review systematically summarizes the classifications of MMPs, their substrates and recognized sequences, and overexpressed tumor types. The advances of MMPs-responsive nanoprobes for cancer diagnosis and therapy are focused, including trigger mechanism, design principle, and various imaging or therapy modes. Finally, this review analyzes the challenges of MMPs-responsive nanoprobes in clinical application, and provides constructive opinions for future study.

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来源期刊

Reviews in Analytical Chemistry 化学-分析化学

CiteScore

7.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.