{"title":"紫荆对扑热息痛肝毒性的保护和抗氧化作用","authors":"S. M. Gunjegaonkar, S. Kshirsagar, J. Bayas","doi":"10.7439/IJPR.V6I3.3061","DOIUrl":null,"url":null,"abstract":"The present study was designed to evaluate Hepatoprotective and antioxidant potential of Tephrosia Purprea whole plant aqueous extract in paracetamol intoxicated rats. 75mg/kg and 150mg/kg of aqueous extract were administered orally once a daily for seven days. Animals were challenged with paracetamol on 5 th day of treatment protocol. Elevated serum levels of transaminases, alkaline phosphatase and bilirubin (direct and total) were restored significantly by the extract. Silymarine (reference standard) exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. The biochemical parameters were supplemented with histopathological studies. In-vitro free radical scavenging activity was screened and results concluded that possible mechanism of hepatoprotective activity may be due to its free radical scavenging activity.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"68 1","pages":"104-108"},"PeriodicalIF":0.0000,"publicationDate":"2016-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Hepatoprotective and Antioxidant potential of Tephrosia Purprea in Paracetamol Induced Hepatotoxicity\",\"authors\":\"S. M. Gunjegaonkar, S. Kshirsagar, J. Bayas\",\"doi\":\"10.7439/IJPR.V6I3.3061\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study was designed to evaluate Hepatoprotective and antioxidant potential of Tephrosia Purprea whole plant aqueous extract in paracetamol intoxicated rats. 75mg/kg and 150mg/kg of aqueous extract were administered orally once a daily for seven days. Animals were challenged with paracetamol on 5 th day of treatment protocol. Elevated serum levels of transaminases, alkaline phosphatase and bilirubin (direct and total) were restored significantly by the extract. Silymarine (reference standard) exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. The biochemical parameters were supplemented with histopathological studies. In-vitro free radical scavenging activity was screened and results concluded that possible mechanism of hepatoprotective activity may be due to its free radical scavenging activity.\",\"PeriodicalId\":14194,\"journal\":{\"name\":\"International Journal of Pharmacological Research\",\"volume\":\"68 1\",\"pages\":\"104-108\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Pharmacological Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7439/IJPR.V6I3.3061\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmacological Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7439/IJPR.V6I3.3061","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hepatoprotective and Antioxidant potential of Tephrosia Purprea in Paracetamol Induced Hepatotoxicity
The present study was designed to evaluate Hepatoprotective and antioxidant potential of Tephrosia Purprea whole plant aqueous extract in paracetamol intoxicated rats. 75mg/kg and 150mg/kg of aqueous extract were administered orally once a daily for seven days. Animals were challenged with paracetamol on 5 th day of treatment protocol. Elevated serum levels of transaminases, alkaline phosphatase and bilirubin (direct and total) were restored significantly by the extract. Silymarine (reference standard) exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. The biochemical parameters were supplemented with histopathological studies. In-vitro free radical scavenging activity was screened and results concluded that possible mechanism of hepatoprotective activity may be due to its free radical scavenging activity.
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