isatin及其衍生物的化学、药理、生物活性综述-第1部分(1877 - 2002)

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摘要

Isatin是一种天然存在的物质,存在于人类、动物、植物和煤焦油中。isatin本身表现出多种生物效应(体内和体外),据报道,取代isatins具有广泛的药理学特性,如抗菌、抗肿瘤、镇痛、抗炎、解热、酶活性、中枢神经系统活性、抗原虫、抗蠕虫和与生物分子的关联。在这篇综述文章中,我们试图汇编最重要的报告(1877年至2002年)的isatin及其衍生物的生物学和药理活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review of Chemical, Pharmacological, Biological Activities of Isatin and its Derivatives – Part-1 (1877 to 2002)
:Isatin is a naturally occurring substance present in humans, animals, plants and coal tar. Isatin itself exhibits a variety of biological effects (invivo and invitro) and substituted isatins are reported to possess a wide range of pharmacological properties such as antimicrobial, antineoplastic, analgesic, antiinflammatory, antipyretic, enzyme activity, CNS activity, antiprotozoal, antihelminthic and association with biomolecules. In this review article, we have attempted to compile the most signigicant reports (1877 to 2002) of biological and pharmacological activites of isatin and its derivatives.
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