纳米技术:纳米医学、纳米毒性和未来的挑战

Vinod Kumar, A. Choudhary, Prashanth Kumar, Saurabh Sharma
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引用次数: 20

摘要

本文通过对纳米载体、靶向基团和具有光学和磁性的药物之间的关系的理解,概述了纳米粒子的有趣性质,发现纳米药物的潜在应用以及在开发纳米药物时需要考虑的问题,如毒性。在这里,我们将纳米材料的有趣性质与其在活细胞/身体中的应用联系起来,同时也详细讨论了纳米药物的承诺、前景和毒性挑战。举例说明了金纳米颗粒及其衍生物的使用,如异杂和纯杂化纳米结构,使其可以用作造影剂、治疗实体和支持附加功能分子和靶向配体以及分子框架结构。在此,我们对纳米药物的潜在应用前景进行了展望。这些纳米材料已被用于各种生物医学应用,如靶向药物输送、光热、癌症治疗、MRI、光学成像等,在体外和体内。综上所述,本文综述了纳米医学和可能的纳米毒性领域的许多方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanotechnology: Nanomedicine, Nanotoxicity and Future Challenges
This review gives an overview of interesting properties of nanoparticles finding potential applications in nanomedicines and their considerations that need to be made such as toxicity while developing a nanomedicine by providing an understanding of a relationship between nanocarrier, targeting moieties and drugs with optical and magnetic properties. Here, we correlate the interesting properties of nanomaterials to their applications in living cells/body simultaneously promises, prospects and toxicity challenges of nanomedicines have also been discussed in detail. Exemplifying the usage of gold nanoparticles and its derivatives such as hetero and homo hybrid nanostructures that allow their use as contrast agents, therapeutic entities and supports to attach functional molecules and targeting ligand along with molecular framework structures. Here, we present the future prospects for potential applications in nanomedicines. These nanomaterials have been used for varieties of biomedical applications such as targeted drug delivery, photothermal cancer therapies, MRI, optical imaging, etc. in vitro and in vivo. In summary, this review provides innumerable aspects in the emerging field of nanomedicine and possible nanotoxicity.
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