Kishore Kumar Shil, M. Hasan, N. Sultana, Sayad Bin Abdus Salam, M. Hasanat
{"title":"新诊断的青年型2型糖尿病的高血糖漂移可能与Â-Cell分泌能力有关，而与胰岛素抵抗无关","authors":"Kishore Kumar Shil, M. Hasan, N. Sultana, Sayad Bin Abdus Salam, M. Hasanat","doi":"10.3329/bjm.v34i20.66169","DOIUrl":null,"url":null,"abstract":"Background: Youth-onset type 2 Diabetes mellitus (T2DM) often presents with high glycemic values.To see the plasma glucose and hemoglobin A1c (HBA1c) at diagnosis and their relationship with â-cell secretory capacity and insulin resistance in phenotypic T2DM of young.\nMethods: This cross-sectional study enrolled 72 newlydiagnosed youth-onset phenotypically T2DM [age range 19-29, median 27, inter-quartile range (IQR) 24-29 years; male 32 (44.4%), female 40 (55.6%)] during March-December’2022 in Endocrinology department, BSMMU. The secretory capacity of â-cell was estimated by fasting C-peptide (measured by chemiluminescence immunoassay) and insulin resistance by calculating visceral adiposity index (VAI) and serum triglyceride/highdensity lipoprotein (TH/HDL) ratio.\nResults: Median HbA1c, fasting plasma glucose (FPG), and 2h plasma glucose (2h-PG) of the participants were 8.7% (IQR 6.7-11.0), 10.8 (IQR 7.1-16.3) mmol/L and 18.0 (IQR 13.1- 24.3) mmol/L respectively. All glycemic values were negatively correlated to fasting C-peptide (HbA1c: r=-0.437, p<0.001; FPG: r=-0.479, p<0.001; 2h-PG: r=-0.456, p<0.001), body mass index (HbA1c: r=-0.546, p<0.001; FPG: r=- 0.550, p<0.001; 2h-PG: r=-0.505, p<0.001) and waist circumference (HbA1c: r=-0.422, p<0.001; FPG: r=-0.399, p=0.001; 2h-PG: r=-0.361, p=0.002). There were no significant correlations of any glycemic values to VAI (HbA1c: r=-0.037, p=0.757; FPG: r=0.075, p=0.532; 2h-PG: r=0.136, p=0.254) or TG/HDL ratio (HbA1c: r=0.036, p=0.764; FPG: r=0.144, p=0.228; 2h-PG: r=0.196, p=0.099). In a linear regression model adjusted for VAI, each nmol reduction of C-peptide was associated with 0.49 (95%CI 0.19-0.79) rise of HbA1c% (p=0.002).\nConclusion: Higher glycemic excursion at diagnosis of youth-onset T2DM is related to lower â-cells reserve and lower obesity indices but not to insulin resistance.\nBangladesh J Medicine 2023; Vol. 34, No. 2(1) Supplement: 214-215 ","PeriodicalId":8721,"journal":{"name":"Bangladesh Journal of Veterinary Medicine","volume":"56 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Higher Glycemic Excursion of Newly Diagnosed Youthonset Type-2 Diabetes Mellitus May Be Related to Â-Cell Secretory Capacity and Not to Insulin Resistance\",\"authors\":\"Kishore Kumar Shil, M. Hasan, N. Sultana, Sayad Bin Abdus Salam, M. Hasanat\",\"doi\":\"10.3329/bjm.v34i20.66169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Youth-onset type 2 Diabetes mellitus (T2DM) often presents with high glycemic values.To see the plasma glucose and hemoglobin A1c (HBA1c) at diagnosis and their relationship with â-cell secretory capacity and insulin resistance in phenotypic T2DM of young.\\nMethods: This cross-sectional study enrolled 72 newlydiagnosed youth-onset phenotypically T2DM [age range 19-29, median 27, inter-quartile range (IQR) 24-29 years; male 32 (44.4%), female 40 (55.6%)] during March-December’2022 in Endocrinology department, BSMMU. The secretory capacity of â-cell was estimated by fasting C-peptide (measured by chemiluminescence immunoassay) and insulin resistance by calculating visceral adiposity index (VAI) and serum triglyceride/highdensity lipoprotein (TH/HDL) ratio.\\nResults: Median HbA1c, fasting plasma glucose (FPG), and 2h plasma glucose (2h-PG) of the participants were 8.7% (IQR 6.7-11.0), 10.8 (IQR 7.1-16.3) mmol/L and 18.0 (IQR 13.1- 24.3) mmol/L respectively. All glycemic values were negatively correlated to fasting C-peptide (HbA1c: r=-0.437, p<0.001; FPG: r=-0.479, p<0.001; 2h-PG: r=-0.456, p<0.001), body mass index (HbA1c: r=-0.546, p<0.001; FPG: r=- 0.550, p<0.001; 2h-PG: r=-0.505, p<0.001) and waist circumference (HbA1c: r=-0.422, p<0.001; FPG: r=-0.399, p=0.001; 2h-PG: r=-0.361, p=0.002). There were no significant correlations of any glycemic values to VAI (HbA1c: r=-0.037, p=0.757; FPG: r=0.075, p=0.532; 2h-PG: r=0.136, p=0.254) or TG/HDL ratio (HbA1c: r=0.036, p=0.764; FPG: r=0.144, p=0.228; 2h-PG: r=0.196, p=0.099). In a linear regression model adjusted for VAI, each nmol reduction of C-peptide was associated with 0.49 (95%CI 0.19-0.79) rise of HbA1c% (p=0.002).\\nConclusion: Higher glycemic excursion at diagnosis of youth-onset T2DM is related to lower â-cells reserve and lower obesity indices but not to insulin resistance.\\nBangladesh J Medicine 2023; Vol. 34, No. 2(1) Supplement: 214-215 \",\"PeriodicalId\":8721,\"journal\":{\"name\":\"Bangladesh Journal of Veterinary Medicine\",\"volume\":\"56 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bangladesh Journal of Veterinary Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3329/bjm.v34i20.66169\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bangladesh Journal of Veterinary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/bjm.v34i20.66169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Higher Glycemic Excursion of Newly Diagnosed Youthonset Type-2 Diabetes Mellitus May Be Related to Â-Cell Secretory Capacity and Not to Insulin Resistance
Background: Youth-onset type 2 Diabetes mellitus (T2DM) often presents with high glycemic values.To see the plasma glucose and hemoglobin A1c (HBA1c) at diagnosis and their relationship with â-cell secretory capacity and insulin resistance in phenotypic T2DM of young.
Methods: This cross-sectional study enrolled 72 newlydiagnosed youth-onset phenotypically T2DM [age range 19-29, median 27, inter-quartile range (IQR) 24-29 years; male 32 (44.4%), female 40 (55.6%)] during March-December’2022 in Endocrinology department, BSMMU. The secretory capacity of â-cell was estimated by fasting C-peptide (measured by chemiluminescence immunoassay) and insulin resistance by calculating visceral adiposity index (VAI) and serum triglyceride/highdensity lipoprotein (TH/HDL) ratio.
Results: Median HbA1c, fasting plasma glucose (FPG), and 2h plasma glucose (2h-PG) of the participants were 8.7% (IQR 6.7-11.0), 10.8 (IQR 7.1-16.3) mmol/L and 18.0 (IQR 13.1- 24.3) mmol/L respectively. All glycemic values were negatively correlated to fasting C-peptide (HbA1c: r=-0.437, p<0.001; FPG: r=-0.479, p<0.001; 2h-PG: r=-0.456, p<0.001), body mass index (HbA1c: r=-0.546, p<0.001; FPG: r=- 0.550, p<0.001; 2h-PG: r=-0.505, p<0.001) and waist circumference (HbA1c: r=-0.422, p<0.001; FPG: r=-0.399, p=0.001; 2h-PG: r=-0.361, p=0.002). There were no significant correlations of any glycemic values to VAI (HbA1c: r=-0.037, p=0.757; FPG: r=0.075, p=0.532; 2h-PG: r=0.136, p=0.254) or TG/HDL ratio (HbA1c: r=0.036, p=0.764; FPG: r=0.144, p=0.228; 2h-PG: r=0.196, p=0.099). In a linear regression model adjusted for VAI, each nmol reduction of C-peptide was associated with 0.49 (95%CI 0.19-0.79) rise of HbA1c% (p=0.002).
Conclusion: Higher glycemic excursion at diagnosis of youth-onset T2DM is related to lower â-cells reserve and lower obesity indices but not to insulin resistance.
Bangladesh J Medicine 2023; Vol. 34, No. 2(1) Supplement: 214-215
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