富多糖山茱萸提取物的抗炎、抗血管生成及抗氧化活性

Allisson Jhonathan Gomes Castro , Luiza Sheyla E.P. Will Castro , Marília S. Nascimento Santos , Monique G.C. Faustino , Thuane S. Pinheiro , Celina M.P. Guerra Dore , Iuri G. Baseia , Edda Lisboa Leite
{"title":"富多糖山茱萸提取物的抗炎、抗血管生成及抗氧化活性","authors":"Allisson Jhonathan Gomes Castro ,&nbsp;Luiza Sheyla E.P. Will Castro ,&nbsp;Marília S. Nascimento Santos ,&nbsp;Monique G.C. Faustino ,&nbsp;Thuane S. Pinheiro ,&nbsp;Celina M.P. Guerra Dore ,&nbsp;Iuri G. Baseia ,&nbsp;Edda Lisboa Leite","doi":"10.1016/j.bionut.2013.08.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Extract rich in glucans from the </span><em>Caripia montagnei</em><span> mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin<span> and parecoxib. Agonists of PPARα showed a value of 90.8</span></span> <!-->±<!--> <!-->10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9<!--> <!-->±<!--> <span><span>7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in </span>leukocyte migration<span><span>, in addition to modest nitric oxide production. The polymer </span>antiangiogenic activity showed a high inhibiting concentration of 1000</span></span> <span>μg/egg. This study also investigated total antioxidant activity (57</span> <!-->±<!--> <!-->0.3%), reducing power (37.6<!--> <!-->±<!--> <span>0.16), and lipid peroxidation (84</span> <!-->±<!--> <span>0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0</span> <!-->±<!--> <!-->0.01% (1<!--> <!-->mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from <em>Caripia montagnei</em><span> has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.</span></p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.004","citationCount":"17","resultStr":"{\"title\":\"Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei\",\"authors\":\"Allisson Jhonathan Gomes Castro ,&nbsp;Luiza Sheyla E.P. Will Castro ,&nbsp;Marília S. Nascimento Santos ,&nbsp;Monique G.C. Faustino ,&nbsp;Thuane S. Pinheiro ,&nbsp;Celina M.P. Guerra Dore ,&nbsp;Iuri G. Baseia ,&nbsp;Edda Lisboa Leite\",\"doi\":\"10.1016/j.bionut.2013.08.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Extract rich in glucans from the </span><em>Caripia montagnei</em><span> mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin<span> and parecoxib. Agonists of PPARα showed a value of 90.8</span></span> <!-->±<!--> <!-->10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9<!--> <!-->±<!--> <span><span>7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in </span>leukocyte migration<span><span>, in addition to modest nitric oxide production. The polymer </span>antiangiogenic activity showed a high inhibiting concentration of 1000</span></span> <span>μg/egg. This study also investigated total antioxidant activity (57</span> <!-->±<!--> <!-->0.3%), reducing power (37.6<!--> <!-->±<!--> <span>0.16), and lipid peroxidation (84</span> <!-->±<!--> <span>0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0</span> <!-->±<!--> <!-->0.01% (1<!--> <!-->mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from <em>Caripia montagnei</em><span> has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.</span></p></div>\",\"PeriodicalId\":100182,\"journal\":{\"name\":\"Biomedicine & Preventive Nutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.004\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedicine & Preventive Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210523913000500\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210523913000500","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17

摘要

富葡聚糖提取液的抗水肿活性高于非甾体抗炎药(NSAIDs)、吲哚美辛和帕瑞昔布。ppara受体激动剂为90.8±10.9%,ppara受体激动剂罗格列酮为41.9±7.1%。实验动物模型,卡拉胶性胸膜炎,发现这种多糖也显示出抗炎作用。除了少量一氧化氮产生外,白细胞迁移也发生严重减少。该聚合物抗血管生成活性表现出较高的抑制浓度(1000 μg/卵)。研究了其总抗氧化活性(57±0.3%)、还原能力(37.6±0.16)和脂质过氧化能力(84±0.51%)。对羟基自由基的抑制作用为38.0±0.01% (1 mg/mL),对铁螯合有较高的抑制作用。结果表明,山茱萸β-葡聚糖含量在炎症模型、血管生成和自由基抑制中具有显著的药理活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei

Extract rich in glucans from the Caripia montagnei mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and parecoxib. Agonists of PPARα showed a value of 90.8 ± 10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9 ± 7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in leukocyte migration, in addition to modest nitric oxide production. The polymer antiangiogenic activity showed a high inhibiting concentration of 1000 μg/egg. This study also investigated total antioxidant activity (57 ± 0.3%), reducing power (37.6 ± 0.16), and lipid peroxidation (84 ± 0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0 ± 0.01% (1 mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from Caripia montagnei has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信