Allisson Jhonathan Gomes Castro , Luiza Sheyla E.P. Will Castro , Marília S. Nascimento Santos , Monique G.C. Faustino , Thuane S. Pinheiro , Celina M.P. Guerra Dore , Iuri G. Baseia , Edda Lisboa Leite
{"title":"富多糖山茱萸提取物的抗炎、抗血管生成及抗氧化活性","authors":"Allisson Jhonathan Gomes Castro , Luiza Sheyla E.P. Will Castro , Marília S. Nascimento Santos , Monique G.C. Faustino , Thuane S. Pinheiro , Celina M.P. Guerra Dore , Iuri G. Baseia , Edda Lisboa Leite","doi":"10.1016/j.bionut.2013.08.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Extract rich in glucans from the </span><em>Caripia montagnei</em><span> mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin<span> and parecoxib. Agonists of PPARα showed a value of 90.8</span></span> <!-->±<!--> <!-->10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9<!--> <!-->±<!--> <span><span>7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in </span>leukocyte migration<span><span>, in addition to modest nitric oxide production. The polymer </span>antiangiogenic activity showed a high inhibiting concentration of 1000</span></span> <span>μg/egg. This study also investigated total antioxidant activity (57</span> <!-->±<!--> <!-->0.3%), reducing power (37.6<!--> <!-->±<!--> <span>0.16), and lipid peroxidation (84</span> <!-->±<!--> <span>0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0</span> <!-->±<!--> <!-->0.01% (1<!--> <!-->mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from <em>Caripia montagnei</em><span> has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.</span></p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.004","citationCount":"17","resultStr":"{\"title\":\"Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei\",\"authors\":\"Allisson Jhonathan Gomes Castro , Luiza Sheyla E.P. Will Castro , Marília S. Nascimento Santos , Monique G.C. Faustino , Thuane S. Pinheiro , Celina M.P. Guerra Dore , Iuri G. Baseia , Edda Lisboa Leite\",\"doi\":\"10.1016/j.bionut.2013.08.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Extract rich in glucans from the </span><em>Caripia montagnei</em><span> mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin<span> and parecoxib. Agonists of PPARα showed a value of 90.8</span></span> <!-->±<!--> <!-->10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9<!--> <!-->±<!--> <span><span>7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in </span>leukocyte migration<span><span>, in addition to modest nitric oxide production. The polymer </span>antiangiogenic activity showed a high inhibiting concentration of 1000</span></span> <span>μg/egg. This study also investigated total antioxidant activity (57</span> <!-->±<!--> <!-->0.3%), reducing power (37.6<!--> <!-->±<!--> <span>0.16), and lipid peroxidation (84</span> <!-->±<!--> <span>0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0</span> <!-->±<!--> <!-->0.01% (1<!--> <!-->mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from <em>Caripia montagnei</em><span> has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.</span></p></div>\",\"PeriodicalId\":100182,\"journal\":{\"name\":\"Biomedicine & Preventive Nutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.004\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedicine & Preventive Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210523913000500\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210523913000500","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei
Extract rich in glucans from the Caripia montagnei mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and parecoxib. Agonists of PPARα showed a value of 90.8 ± 10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9 ± 7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in leukocyte migration, in addition to modest nitric oxide production. The polymer antiangiogenic activity showed a high inhibiting concentration of 1000μg/egg. This study also investigated total antioxidant activity (57 ± 0.3%), reducing power (37.6 ± 0.16), and lipid peroxidation (84 ± 0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0 ± 0.01% (1 mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from Caripia montagnei has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.