2019年新型冠状病毒核酸检测假阴性结果分析及对策

Q4 Health Professions

中华检验医学杂志 Pub Date : 2020-02-14 DOI:10.3760/CMA.J.ISSN.1009-9158.2010.0006

Jin Li, Guangming Ye, Liangjun Chen, Jiajun Wang, Yirong Li

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引用次数: 17

摘要

2019年12月，一群不明原因肺炎患者与中国武汉的一个海鲜批发市场有关。一些研究发现，这种病毒是一种从未在人体中发现的新型病毒。随后，该病毒被世界卫生组织命名为2019年新型冠状病毒(2019- ncov)。新型冠状病毒核酸检测是诊断新型冠状病毒肺炎的重要指标之一。最近，中日友好医院和杭州医院的一些假阴性病例让临床医生对核酸检测的价值产生了质疑。本文对武汉大学中南医院3000多例新型冠状病毒检测结果进行分析。应重视产生假阴性结果的根本原因，并采取相应的对策。关键词:冠状病毒;核酸;聚合酶链反应;虚假负面反应;质量控制

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Analysis of false-negative results for 2019 novel coronavirus nucleic acid test and related countermeasures/ 中华检验医学杂志

In December 2019, a cluster of patients with pneumonia of unknown cause were linked to a seafood wholesale market in Wuhan, China. Some studies found that the virus was a new kind of virus which had never been found in the human body. Then, the virus was named 2019 Novel Coronavirus (2019-nCoV) by the World Health Organization (WHO). 2019-nCoV nucleic acid detection is one of the essential indicators of NCP (Novel Coronavirus Pneumonia). Recently, some false-negative cases in China-Japan Friendship Hospital and Hangzhou Hospital led the clinical doctors to question the value of the nucleic acid detection. In this paper, more than 3 000 results of 2019-nCoV detection in Zhongnan Hospital, Wuhan University were analyzed. Attention should be paid to the root cause of false-negative results and the related countermeasures should be taken. Key words: Coronavirus; Nucleic acids; Polymerase chain reaction; False negative reactions; Quality control

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来源期刊

中华检验医学杂志 Health Professions-Medical Laboratory Technology

CiteScore

0.40

自引率

0.00%

发文量

8037

期刊介绍：