Q4 Medicine
Neşe Yeldi̇r, E. Doğan, Hatice Özer, Burçak Söylemez, Serkan Çeli̇kgün, Reyhan Eğilmez
{"title":"Meningiomlarda Ki-67 Proliferasyon İndeks Pozitiflik Sınır Değeri","authors":"Neşe Yeldi̇r, E. Doğan, Hatice Özer, Burçak Söylemez, Serkan Çeli̇kgün, Reyhan Eğilmez","doi":"10.47493/abantmedj.1177937","DOIUrl":null,"url":null,"abstract":"Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization (WHO) classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit (cut-off) value of the Ki-67 proliferation index in cases diagnosed with meningioma.\nThe Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values.\nThe mean Ki-67 proliferation index was found to be 3% for grade 1, 8% for grade 2 and 17% for grade 3 in the cases diagnosed with meningioma in our center.\nThe Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6,5 (p>0,05).","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Duzce Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47493/abantmedj.1177937","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

根据世界卫生组织(WHO)的分类,脑膜瘤通常是生长缓慢的1级肿瘤。定义了判定高级别和侵袭性脑膜瘤的组织学和分子标准。在组织病理学标准中也考虑了增殖活性。测定增殖活性的一个常用参数是Ki-67指数。本研究是回顾性形成的,目的是确定脑膜瘤病例中Ki-67增殖指数的阳性界限(临界值)。对190例脑膜瘤患者的Ki-67指标与肿瘤的组织学程度进行比较。Ki-67值采用ROC分析方法进行统计分析。在本中心诊断为脑膜瘤的病例中,Ki-67增殖指数平均为1级3%,2级8%,3级17%。Ki-67增殖指数除组织病理学检查外,还可作为我们实验室区分1级和2级脑膜瘤的依据,其阳性极限值为6,5 (p> 0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Meningiomlarda Ki-67 Proliferasyon İndeks Pozitiflik Sınır Değeri
Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization (WHO) classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit (cut-off) value of the Ki-67 proliferation index in cases diagnosed with meningioma. The Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values. The mean Ki-67 proliferation index was found to be 3% for grade 1, 8% for grade 2 and 17% for grade 3 in the cases diagnosed with meningioma in our center. The Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6,5 (p>0,05).
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Duzce Medical Journal
Duzce Medical Journal Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
59
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信